Gold nanoparticles in chemo-, immuno-, and combined therapy: review [Invited]
L. A. Dykman,N. G. Khlebtsov +1 more
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This review summarizes recent data and topical problems in nanomedicine that are related to the use of variously sized, shaped, and structured GNPs.Abstract:
Functionalized gold nanoparticles (GNPs) with controlled geometrical and optical properties have been the subject of intense research and biomedical applications. This review summarizes recent data and topical problems in nanomedicine that are related to the use of variously sized, shaped, and structured GNPs. We focus on three topical fields in current nanomedicine: (1) use of GNP-based nanoplatforms for the targeted delivery of anticancer and antimicrobial drugs and of genes; (2) GNP-based cancer immunotherapy; and (3) combined chemo-, immuno-, and phototherapy. We present a summary of the available literature data and a short discussion of future work.read more
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Gold nanoparticles-mediated photothermal therapy and immunotherapy.
TL;DR: GNS-mediated photothermal therapy combined with checkpoint immunotherapy has been found to reverse tumor-mediated immunosuppression, thereby leading to the treatment of not only primary tumors but also cancer metastasis, as well as to induce effective long-lasting immunity, in other words, an anticancer 'vaccine' effect.
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Role of gold nanoparticles in advanced biomedical applications
TL;DR: The recent advancements of GNPs are evaluated to highlight their exceptional potential in the biomedical field, with special focus given to emerging biomedical applications including bio-imaging, site specific drug/gene delivery, nano-sensing, diagnostics, photon induced therapeutics, and theranostics.
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An overview of the plant-mediated green synthesis of noble metal nanoparticles for antibacterial applications
Farahnaz Behzad,Farahnaz Behzad,Seyed Morteza Naghib,Mohammad Amin Jadidi Kouhbanani,Seyede Nafise Tabatabaei,Yasser Zare,Kyong Yop Rhee +6 more
TL;DR: The developments of NMNPs are highlighted for resolving existing toxicity concerns, their antimicrobial effects, as well as the future challenges in this field.
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Gold nanoparticles: Synthesis properties and applications
TL;DR: AuNPs have shown outstanding applications for diagnostic and therapeutic uses, including biosensor applications, tumor-targeting capability (Anticancer Activity) for cancer therapy, and precise drug delivery of nano-vehicles to diseased tissues.
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Recent advancement of imidazolate framework (ZIF-8) based nanoformulations for synergistic tumor therapy.
TL;DR: This review will summarize the recent advancement of ZIF-8 as nanocarriers for the loading of various molecules including chemotherapeutic drugs, photosensitizers, photothermal agents, and proteins to fabricate multifunctional nanocomposites for synergistic cancer therapy.
References
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Analysis of nanoparticle delivery to tumours
Stefan Wilhelm,Anthony J. Tavares,Qin Dai,Seiichi Ohta,Seiichi Ohta,Julie Audet,Harold F. Dvorak,Warren C. W. Chan +7 more
TL;DR: This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘ how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?'
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The golden age: gold nanoparticles for biomedicine
TL;DR: It is argued that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us.
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Nanoparticle-mediated cellular response is size-dependent
TL;DR: It is shown that gold and silver nanoparticles coated with antibodies can regulate the process of membrane receptor internalization and show that nanoparticles should no longer be viewed as simple carriers for biomedical applications, but can also play an active role in mediating biological effects.
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Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity
Elodie Boisselier,Didier Astruc +1 more
TL;DR: This critical review provides an overall survey of the basic concepts and up-to-date literature results concerning the very promising use of gold nanoparticles (AuNPs) for medicinal applications.
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Gold nanoparticles in biomedical applications: recent advances and perspectives
TL;DR: This critical review is focused on the application of GNP conjugates to biomedical diagnostics and analytics, photothermal and photodynamic therapies, and delivery of target molecules.