Journal ArticleDOI
Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio)
Eduarda M. Santos,Gregory C. Paull,Katrien J. W. Van Look,Victoria Louise Workman,William V. Holt,Ronny van Aerle,Peter Kille,Charles R. Tyler +7 more
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TLDR
It was demonstrated that EE(2) exposure compromised the reproductive health of breeding zebrafish at environmentally relevant concentrations and the molecular mechanisms mediating some of these effects were identified and included those impacting processes central to gametogenesis in both males and females.About:
This article is published in Aquatic Toxicology.The article was published on 2007-06-15. It has received 93 citations till now. The article focuses on the topics: Environmental exposure & Zebrafish.read more
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A critical analysis of the biological impacts of plasticizers on wildlife.
Jörg Oehlmann,Ulrike Schulte-Oehlmann,Werner Kloas,Oana Jagnytsch,Ilka Lutz,Kresten Ole Kusk,Leah Wollenberger,Eduarda M. Santos,Gregory C. Paull,Katrien J. W. Van Look,Charles R. Tyler +10 more
TL;DR: Most plasticizers appear to act by interfering with the functioning of various hormone systems, but some phthalates have wider pathways of disruption, and given the sensitivity of some invertebrates, effects assessments are warranted in other invertebrate phyla.
Journal ArticleDOI
Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish.
TL;DR: The authors review the current data on the presence and reported biological effects in fish of some of the most commonly detected pharmaceuticals in the aquatic environment; namely nonsteroidal anti-inflammatory drugs (NSAIDs), fibrates, β-blockers, selective serotonin reuptake inhibitors (SSRIs), azoles, and antibiotics.
Journal ArticleDOI
Developmental exposure of zebrafish (Danio rerio) to bisphenol-S impairs subsequent reproduction potential and hormonal balance in adults.
TL;DR: Developmental exposure to low concentrations of BPS has adverse effects on different parts of the endocrine system in zebrafish, and the consequent effects on fish development, reproduction, plasma vitellogenin, sex steroids and thyroid hormone levels were investigated.
Journal ArticleDOI
Factors enhancing fish sperm quality and emerging tools for sperm analysis
Elsa Cabrita,Elsa Cabrita,S. Martínez-Páramo,Paulo J. Gavaia,Marta F. Riesco,David G. Valcarce,Carmen Sarasquete,María Paz Herráez,Vanesa Robles +8 more
TL;DR: A comprehensive overview of the current methods used in research to assess sperm quality is given, in new trends on sperm analysis, and in the use of these tools for the identification of factors enhancing gamete quality.
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Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka.
Xiaowei Zhang,Markus Hecker,Markus Hecker,June-Woo Park,Amber R. Tompsett,John L. Newsted,Kei Nakayama,Paul D. Jones,Paul D. Jones,Doris W.T. Au,Richard Y.C. Kong,Rudolf S.S. Wu,John P. Giesy +12 more
TL;DR: The results suggested that the Japanese medaka HPG-PCR array has potential not only as a screening tool of potential endocrine-disrupting chemicals but also in elucidating mechanisms of action.
References
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Journal ArticleDOI
Widespread Sexual Disruption in Wild Fish
TL;DR: This paper demonstrates a high incidence of intersexuality in wild populations of riverine fish (roach; Rutilus rutilus) throughout the United Kingdom and indicates that reproductive and developmental effects do result from exposure to ambient levels of chemicals present in typical British rivers.
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Endocrine Disruption in Wildlife: A Critical Review of the Evidence
TL;DR: The evidence, from both laboratory and field studies, that exposure to steroid hormone mimics may impair reproductive function is reviewed and the weight of evidence for endocrine disruption in wildlife is critically assessed.
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Oocyte growth and development in teleosts
Charles R. Tyler,John P. Sumpter +1 more
TL;DR: The mechanisms that control oocyte growth are addressed in this review, albeit that the available information, as in all other vertebrates, is very limited.
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Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish.
Jon P. Nash,David E. Kime,Leo T.M. van der Ven,P.W. Wester,François Brion,Gerd Maack,Petra Stahlschmidt-Allner,Charles R. Tyler +7 more
TL;DR: These findings raise major concerns about the population-level impacts for wildlife of long-term exposure to low concentrations of estrogenic endocrine disruptors, especially in group-spawning fish.
Journal Article
Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.
H Shibata,Thomas E. Spencer,Sergio A. Onate,Guido Jenster,Sophia Y. Tsai,Ming-Jer Tsai,Bert W. O'Malley +6 more
TL;DR: A ternary complex-consisting of CBP, SRC-1, and liganded steroid receptors-may form to increase the rate of hormone-responsive gene transcription and enhance transactivation of steroid hormone-dependent target genes.