Journal ArticleDOI
Grass carps co-exposed to environmentally relevant concentrations of cypermethrin and sulfamethoxazole bear immunodeficiency and are vulnerable to subsequent Aeromonas hydrophila infection.
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TLDR
By affecting the conduction of TLR signaling pathway, CMN or/and SMZ exposure inhibits the innate immune response of fish and reducing their disease resistance, highlighting the importance of rational and regulated use of these pesticides and antibiotics.About:
This article is published in Environmental Pollution.The article was published on 2020-11-01. It has received 48 citations till now. The article focuses on the topics: Environmental pollution & Oxidative stress.read more
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Journal ArticleDOI
ROS-Induced Hepatotoxicity under Cypermethrin: Involvement of the Crosstalk between Nrf2/Keap1 and NF-κB/iκB-α Pathways Regulated by Proteasome.
TL;DR: In this article, the toxic phenotype and detoxification mechanism in grass carp (Ctenopharyngodon idella) after treatment with waterborne permethrin (0.651 μg/L) for 6 weeks in vivo or 6.392 μM for 24 hours in vitro.
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Environmentally relevant concentration of cypermethrin or/and sulfamethoxazole induce neurotoxicity of grass carp: Involvement of blood-brain barrier, oxidative stress and apoptosis.
TL;DR: The potential co-ecological risks of pesticide and antibiotic in the aquatic organism will be revealed, and basic data for their safety and risk assessment will be provided.
Journal ArticleDOI
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
TL;DR: In this paper, the authors explored the therapeutic effect of Lycopene on antibiotic (sulfamethoxazole (SMZ) induced intestinal injury in grass carp Ctenopharyngodon idella and found that treatment with LYC significantly suppressed SMZ-induced intestinal epithelial cell damage and tight junction protein destruction.
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Zinc offers splenic protection through suppressing PERK/IRE1-driven apoptosis pathway in common carp (Cyprinus carpio) under arsenic stress.
TL;DR: Treatment with Zn appears to offer protection against As-induced splenic injury in common carp and the pathologic changes above were alleviated, elucidating the role of Zn, a natural immune-modulator, as a potential antidote against As poisoning.
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NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine.
Jingzeng Cai,Haoyue Guan,Xing Jiao,Jie Yang,Xiaoming Chen,Haoran Zhang,Yingying Zheng,Yue Zhu,Qi Liu,Ziwei Zhang +9 more
TL;DR: Zhang et al. as mentioned in this paper investigated the specific molecular mechanisms of Cadmium (Cd) chloride-induced neurotoxicity and found that Cd caused cerebral histopathology lesions, inducing cerebral pyroptosis and the mass generation of inflammatory cytokines, as indicated by the increased NLRP3 inflammasome activation (NLRP3, Cas1 and ASC).
References
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Journal ArticleDOI
Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance.
TL;DR: This is the first comprehensive study which demonstrates an alarming usage and emission of various antibiotics in China and the bacterial resistance rates in the hospitals and aquatic environments were found to be related to the PECs and antibiotic usages, especially for those antibiotics used in the most recent period.
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Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants.
TL;DR: Current knowledge and advances in the understanding of oxidative processes in biological systems are summarized and this knowledge is extended to specific applications in aquatic organisms because of their sensitivity to oxidative pollutants, their filtration capacity, and their potential for environmental toxicology studies.
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Melano-macrophage centres and their role in fish pathology.
C Agius,Ronald J. Roberts +1 more
TL;DR: Recent work suggests that Melano-macrophage centres are a site of primary melanogenesis rather than mere storage, and have been suggested as reliable biomarkers for water quality in terms of both deoxygenation and iatragenic chemical pollution.
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The Function of Fish Cytokines
Jun Zou,Christopher J. Secombes +1 more
TL;DR: Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines, to improve fish health in aquaculture.
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Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China
K. Chen,John L. Zhou +1 more
TL;DR: The spatial distribution of antibiotics showed that the main polluting sources into the Huangpu River were animal farming sites and the tributaries downstream of the Yuanxie River, suggesting the importance of contaminant properties in inter-phase behavior.