Heart Rate and Heart Rate Variability of Rhesus Macaques (Macaca mulatta) Affected by Left Ventricular Hypertrophy.
Yu Ueda,Taylor L. Slabaugh,Ashley L. Walker,Eric S. Ontiveros,Paul Michael D. Sosa,Rachel Reader,Jeffrey A. Roberts,Joshua A. Stern,Joshua A. Stern +8 more
TLDR
ECG analysis and Holter monitoring of rhesus macaques are feasible and that ECG morphological changes in association with LVH could be used as a possible component of an antemortem screening tool, according to the findings.Abstract:
Hypertrophic cardiomyopathy (HCM) is frequently associated with sudden cardiac death, presumably due to the development of malignant arrhythmias. The risk of sudden cardiac death due to HCM has been reported to be predicted by assessing electrocardiographic (ECG) changes including frequencies and complexities of arrhythmias as well as heart rate variability (HRV) as an assessment of autonomic balance. Sudden cardiac death in association with naturally-occurring left ventricular hypertrophy (LVH) has been reported in a colony of rhesus macaques and is under investigation as a potential non-human primate model of human HCM. In the present study, 10 rhesus macaques with LVH and 10 without the signs of LVH confirmed by an echocardiographic examination were recruited for assessing ECG and HRV parameters. ECG morphology on 10-s, 6-lead ECG analysis, and the frequency and complexity of arrhythmias as well as HRV on 20-h ambulatory ECG Holter analyses were assessed. On the standard 10-s 6-lead ECG analysis, P wave and QRS complex duration as well as the QRS complex amplitude were significantly increased in the LVH-affected rhesus macaques compared to control rhesus macaques. Analysis of 20-h Holter monitoring revealed no statistically significant differences in the frequency or the complexity of arrhythmias between the LVH and the control groups. Several HRV parameters were smaller in the LVH group than the control group throughout the majority of Holter recordings showing periods of reduced variability, however, no statistically significant differences were achieved across groups and/or time points. These findings indicate that ECG analysis and Holter monitoring of rhesus macaques are feasible and that ECG morphological changes in association with LVH could be used as a possible component of an antemortem screening tool. The rhesus macaques of this study did not reveal clear indications of risk for sudden cardiac death. Further studies are necessary to determine the etiology of sudden cardiac death due in LVH affected rhesus macaques and identify if any parameters of arrhythmia assessment or HRV can be used to predict the development of sudden cardiac death.read more
Citations
More filters
Journal ArticleDOI
Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)
TL;DR: A review of the most recent updated applications of polysaccharides and their potentialities as alternatives for traditional and conventional therapies is given in this article, where challenges and limitations for polysacchides in pharmaceutical utilities are discussed as well.
Journal ArticleDOI
Coronavirus testing indicates transmission risk increases along wildlife supply chains for human consumption in Viet Nam, 2013-2014
Nguyen Thi Quynh Huong,Nguyen Thi Thanh Nga,Nguyen Van Long,Bach Duc Luu,Alice Latinne,Alice Latinne,Mathieu Pruvot,Nguyen Thanh Phuong,Le Tin Vinh Quang,Vo V. Hung,Nguyen Thi Kim Lan,Nguyen Thi Hoa,Phan Quang Minh,Nguyen Thi Diep,Nguyen Tung,Van Dang Ky,Scott I. Roberton,Hoang Bich Thuy,Martin Gilbert,Leanne Wicker,Jonna A. K. Mazet,Christine K. Johnson,Tracey Goldstein,Alex Tremeau-Bravard,Victoria Ontiveros,Damien O. Joly,Chris Walzer,Chris Walzer,Amanda E. Fine,Sarah H. Olson +29 more
TL;DR: The mixing of multiple coronaviruses, and their apparent amplification along the wildlife supply chain into restaurants, suggests maximal risk for end consumers and likely underpins the mechanisms of zoonotic spillover to people.
Journal ArticleDOI
Biodiversity loss and COVID-19 pandemic: The role of bats in the origin and the spreading of the disease.
TL;DR: The loss of biodiversity in the ecosystems has created the general conditions that have favored and, in fact, made possible, the insurgence of the COVID-19 pandemic.
Journal ArticleDOI
Extracellular Vesicles in Viral Infections: Two Sides of the Same Coin?
TL;DR: Understanding the role of EVs during viral infections is crucial to comprehend viral mechanisms and respond better to emerging viral diseases.
Journal ArticleDOI
Intestinal microbiota and its interaction to intestinal health in nursery pigs
Marcos E Duarte,Sung Woo Kim +1 more
TL;DR: It was demonstrated that the mucosa-associated microbiota should be evaluated when analyzing the interaction among diets, microbiota, and health, and supplementation of feed additives aimed to promote the intestinal health of pigs should consider their roles in the modulation of mucosa -associated microbiota as biomarkers to predict the response of growth performance to dietary interventions.
References
More filters
Journal ArticleDOI
Systematic Review: Process of Forming Academic Service Partnerships to Reform Clinical Education
TL;DR: This study’s findings can provide practical guidelines to steer partnership programs within the academic and clinical bodies, with the aim of providing a collaborative partnership approach to clinical education.
Journal ArticleDOI
Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.
Alan John Camm,Marek Malik,J. T. Bigger,G. Breithardt,Sergio Cerutti,Richard J. Cohen,Philippe Coumel,Ernest L. Fallen,H.L. Kennedy,Robert E. Kleiger,Federico Lombardi,Alberto Malliani,Arthur J. Moss,Jeffrey N. Rottman,Georg Schmidt,Peter J. Schwartz,D.H. Singer +16 more
Journal ArticleDOI
Heart rate variability. Standards of measurement, physiological interpretation, and clinical use
Marek Malik,J. Thomas Bigger,A. John Camm,Robert E. Kleiger,Alberto Malliani,Arthur J. Moss,Peter J. Schwartz +6 more
Journal ArticleDOI
Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog.
Massimo Pagani,Federico Lombardi,Stefano Guzzetti,Ornella Rimoldi,Raffaello Furlan,Paolo Pizzinelli,Giulia Sandrone,Gabriella Malfatto,Simonetta Dell’Orto,E Piccaluga +9 more
TL;DR: The spontaneous beat-to-beat oscillation in R-R interval during control recumbent position, 90° upright tilt, controlled respiration and acute and chronic β-adrenergic receptor blockade was analyzed, indicating that sympathetic nerves to the heart are instrumental in the genesis of low-frequency oscillations in R -R interval.
Journal ArticleDOI
Decreased heart rate variability and its association with increased mortality after acute myocardial infarction
Robert E. Kleiger,Robert E. Kleiger,Robert E. Kleiger,J. Philip Miller,J. Philip Miller,J. Philip Miller,J.Thomas Bigger,J.Thomas Bigger,J.Thomas Bigger,Arthur J. Moss,Arthur J. Moss,Arthur J. Moss +11 more
TL;DR: HR variability remained a significant predictor of mortality after adjusting for clinical, demographic, other Holter features and ejection fraction, and a hypothesis to explain this finding is that decreased HR variability correlates with increased sympathetic or decreased vagal tone, which may predispose to ventricular fibrillation.
Related Papers (5)
Animal board invited review: advances in proteomics for animal and food sciences
André M. Almeida,Anna Bassols,Emøke Bendixen,Mangesh Bhide,Fabrizio Ceciliani,Susana Cristobal,Peter David Eckersall,Kristin Hollung,Frédérique Lisacek,Gabriel Mazzucchelli,Mark McLaughlin,Ingrid Miller,Jarlath E. Nally,Jeffrey E. Plowman,Jenny Renaut,Pedro M. Rodrigues,Paola Roncada,Jože Starič,Romana Turk +18 more