Hematopoietic cells as hepatocyte stem cells: A critical review of the evidence
TLDR
In conclusion, hematopoietic cells contribute little to hepatocyte formation under either physiological or pathological conditions, although they may provide cytokines and growth factors that promote hepatocyte functions by paracrine mechanisms.About:
This article is published in Hepatology.The article was published on 2006-01-01 and is currently open access. It has received 228 citations till now. The article focuses on the topics: Stem cell & Bone marrow.read more
Citations
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Molecular and cellular mechanisms of liver fibrosis and its regression.
TL;DR: This Review summarizes studies of the molecular mechanisms underlying the reversibility of liver fibrosis, including apoptosis and the inactivation of hepatic stellate cells, the crosstalk between the liver and the systems that orchestrate the recruitment of bone marrow-derived macrophages driving fibrosis resolution, and the interactions between various cell types that lead to the intracellular signalling that induces fibrosis or its regression.
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Genomics and signaling pathways in hepatocellular carcinoma.
TL;DR: A review summarizes the most relevant information regarding structural and functional alterations in HCC and describes some of the key signaling pathways implicated in hepatocarcinogenesis.
Journal ArticleDOI
Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells
Dihua Shangguan,Ling Meng,Zehui Charles Cao,Zeyu Xiao,Xiaohong Fang,Ying Li,Diana M. Cardona,Rafal P Witek,Chen Liu,Weihong Tan +9 more
TL;DR: The current study demonstrates that cell-based aptamer selection can select specific aptamers for multiple cell lines, even for two cell lines with minor differences, and opens the door for solid tumor selection and investigation.
Journal Article
Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis
Mehdi Mohamadnejad,Kamran Alimoghaddam,Mandana Mohyeddin-Bonab,M H Bagheri,Maryam Bashtar,Hossein Ghanaati,Hossein Baharvand,Ardeshir Ghavamzadeh,Reza Malekzadeh +8 more
TL;DR: Mesenchymal stem cell transplantation seems to be feasible and safe in the treatment of decompensated liver cirrhosis and the quality of life of all four patients improved by the end of follow-up.
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Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential
L. Valfrè di Bonzo,Ivana Ferrero,Carlo Cravanzola,Katia Mareschi,D Rustichell,Erica Novo,Fiorella Sanavio,Stefania Cannito,E. Zamara,M Bertero,A Davit,S Francica,Francesco Novelli,Sebastiano Colombatto,Franca Fagioli,Maurizio Parola +15 more
TL;DR: Transplanted hMSCs have the potential to migrate into normal and injured liver parenchyma, but differentiation into hepatocyte-like cells is a rare event and pro-fibrogenic potential of hMSC transplant should be not under-evaluated.
References
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Liver regeneration: from myth to mechanism
Rebecca Taub,Rebecca Taub +1 more
TL;DR: The numerous cytokine- and growth-factor-mediated pathways that are involved in regulating liver regeneration are being successfully dissected using molecular and genetic approaches.
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Plasticity of Adult Stem Cells
Amy J. Wagers,Irving L. Weissman +1 more
TL;DR: Current evidence suggests that in vivo such unexpected transformations of adult somatic stem cells are exceedingly rare and in some cases can be accounted for by equally unexpected alternative explanations.
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Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis
TL;DR: The first episode of GI bleeding in patients with liver cirrhosis is associated with high morbidity and mortality, and Renal failure, rebleeding, hepatocellular carcinoma, and hepatic encephalopathy were independent risk factors for early death.
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Nuclear Cloning and Epigenetic Reprogramming of the Genome
TL;DR: Survival of cloned animals to birth and beyond, despite substantial transcriptional dysregulation, is consistent with mammalian development being rather tolerant to epigenetic abnormalities, with lethality resulting only beyond a threshold of faulty gene reprogramming encompassing multiple loci.
Journal Article
A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3.
TL;DR: A morphologic study of DNA synthesis and cellular proliferation in regenerating rat liver has been made by means of incorporation of thymidine-H3 and autoradiography, with results indicating that hepatocytes in zones 1 and 2 accounted for about 80 per cent of this.