Journal ArticleDOI
Hematopoietic Stem-Cell Transplantation
TLDR
Hematopoietic stem-cell transplantation was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically as mentioned in this paper.Abstract:
Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically. This review summarizes background information about hematopoietic stem-cell transplantation and discusses the current role of the procedure.read more
Citations
More filters
Journal ArticleDOI
Acute myeloid leukaemia
Elihu H. Estey,Hartmut Döhner +1 more
TL;DR: Whereas significant progress has been made in the treatment of younger adults, the prospects for elderly patients have remained dismal, with median survival times of only a few months, current efforts in clinical research focus on the assessment of targeted therapies.
Journal ArticleDOI
Gene therapy returns to centre stage
TL;DR: Technology for editing genes and correcting inherited mutations, the engagement of stem cells to regenerate tissues and the effective exploitation of powerful immune responses to fight cancer are also contributing to the revitalization of gene therapy.
Journal ArticleDOI
HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry
Loren Gragert,Mary Eapen,Eric Williams,John Freeman,Stephen R. Spellman,Robert L. Baitty,Robert J. Hartzman,J. Douglas Rizzo,Mary M. Horowitz,Dennis L. Confer,Martin Maiers +10 more
TL;DR: Most patients likely to benefit from HSCT will have a donor, with the highest probability among whites of European descent, and the lowest probability among blacks of South or Central American descent, regardless of racial and ethnic background.
Journal Article
Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Editorial comment
Vanderson Rocha,Eliane Gluckman,Mary Eapen,Pablo Rubinstein,Mei-Jie Zhang,Cladd E. Stevens,Joanne Kurtzberg,Andromachi Scaradavou,Fausto R. Loberiza,Richard E. Champlin,John P. Klein,Mary M. Horowitz,John E. Wagner +12 more
TL;DR: These data support the use of HLA-matched and one- or two-antigen Hla-mismatched umbilical cord blood in children with acute leukaemia who need transplantation and greater investment in large-scale banking is needed to increase HLA diversity.
Journal ArticleDOI
Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study
Mary Eapen,Pablo Rubinstein,Mei-Jie Zhang,Cladd E. Stevens,Joanne Kurtzberg,Andromachi Scaradavou,Fausto R. Loberiza,Richard E. Champlin,John P. Klein,Mary M. Horowitz,John E. Wagner +10 more
TL;DR: In this article, the relative effect of cell dose and HLA match, and their potential interaction on leukaemia-free survival after cord-blood transplantation was assessed, and it was shown that better HLA matching and higher cell doses significantly decrease the risk of transplant-related mortality after umbilical-cord blood transplantation.
References
More filters
Journal ArticleDOI
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.
Journal ArticleDOI
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Tsvee Lapidot,Christian Sirard,Josef Vormoor,Barbara Murdoch,Trang Hoang,Julio R. Caceres-Cortes,Mark D. Minden,Bruce Paterson,Michael A. Caligiuri,John E. Dick +9 more
TL;DR: This in vivo model replicates many aspects of human AML and defines a new leukaemia-initiating cell which is less mature than colony-forming cells.
Journal ArticleDOI
Tumour stem cells and drug resistance
TL;DR: Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might lead to new therapeutic targets and better anticancer strategies.
Journal ArticleDOI
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
Loredana Ruggeri,Marusca Capanni,Elena Urbani,Katia Perruccio,Warren D. Shlomchik,Antonella Tosti,Sabrina Posati,Daniela Rogaia,Francesco Frassoni,Franco Aversa,Massimo F. Martelli,Andrea Velardi +11 more
TL;DR: It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
Journal ArticleDOI
Graft-versus-leukemia reactions after bone marrow transplantation
Mary M. Horowitz,Robert Peter Gale,Paul M. Sondel,John M. Goldman,J. H. Kersey,HJ Kolb,A. A. Rimm,O Ringden,C. Rozman,Bruno Speck +9 more
TL;DR: The results explain the efficacy of allogeneic bone marrow transplantation in eradicating leukemia, provide evidence for a role of the immune system in controlling human cancers, and suggest future directions to improve leukemia therapy.
Related Papers (5)
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report
Madan Jagasia,Hildegard T. Greinix,Mukta Arora,Kirsten M. Williams,Daniel Wolff,Edward W. Cowen,Jeanne Palmer,Daniel J. Weisdorf,Nathaniel S. Treister,Guang-Shing Cheng,Holly Kerr,Pamela Stratton,Rafael F. Duarte,George B. McDonald,Yoshihiro Inamoto,Afonso Celso Vigorito,Sally Arai,Manuel B. Datiles,David A. Jacobsohn,Theo Heller,Carrie L. Kitko,Sandra A. Mitchell,Paul J. Martin,Howard M. Shulman,Roy S. Wu,Corey Cutler,Georgia B. Vogelsang,Stephanie J. Lee,Steven Z. Pavletic,Mary E.D. Flowers +29 more
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
Madan Jagasia,Hildegard T. Greinix,Mukta Arora,Kirsten M. Williams,Daniel Wolff,Edward W. Cowen,Jeanne Palmer,Daniel J. Weisdorf,Nathaniel S. Treister,Guang-Shing Cheng,Holly Kerr,Pamela Stratton,Rafael F. Duarte,George B. McDonald,Yoshihiro Inamoto,Afonso Celso Vigorito,Sally Arai,Manuel B. Datiles,David A. Jacobsohn,Theo Heller,Carrie L. Kitko,Sandra A. Mitchell,Paul J. Martin,Howard M. Shulman,Roy S. Wu,Corey Cutler,Georgia B. Vogelsang,Stephanie J. Lee,Steven Z. Pavletic,Mary E.D. Flowers +29 more