Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate
Malcolm Lyon,Jon A. Deakin,Hassan Rahmoune,David G. Fernig,Toshikazu Nakamura,John T. Gallagher +5 more
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It is demonstrated by affinity chromatography that hepatocyte growth factor/scatter factor (HGF/SF) binds strongly to dermatan sulfate (DS), with a similar ionic strength dependence to that previously seen with heparan sulfATE (HS).About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-01-02 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Glycosaminoglycan binding & Dermatan sulfate.read more
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Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation
TL;DR: This review will discuss progress in immunology and the science of wound repair that has revealed the importance of glycosaminoglycans, and their proteoglycan, in the inflammatory process.
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Dermatan sulfate: new functions from an old glycosaminoglycan.
TL;DR: Dermatan and dermatan sulfate proteoglycans have also been implicated in cardiovascular disease, tumorigenesis, infection, wound repair, and fibrosis as mentioned in this paper, and growing evidence suggests that this glycosaminoglycan is an important cofactor in a variety of cell behaviors.
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Heparan sulfate: a complex polymer charged with biological activity.
MINI REVIEW Dermatan sulfate: new functions from an old glycosaminoglycan
TL;DR: Growing evidence suggests that this glycosaminoglycan, like the better studied heparin and heparan sulfate, is an important cofactor in a variety of cell behaviors.
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Acid and neutral sphingomyelinases: roles and mechanisms of regulation.
Norma Marchesini,Yusuf A. Hannun +1 more
TL;DR: The molecular mechanisms that regulate these enzymes in vivo and in vitro are focused on, especially the roles of oxidants (glutathione, peroxide, nitric oxide), proteins, and lipids (diacylglycerol, arachidonic acid, and ceramide).
References
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Molecular cloning and expression of human hepatocyte growth factor
Toshikazu Nakamura,Tsutomu Nishizawa,Mitchio Hagiya,Tatsuya Seki,Manabu Shimonishi,Atsushi Sugimura,Kosuke Tashiro,Shin Shimizu +7 more
TL;DR: The nucleotide sequence of the human HGF cDNA reveals that both α- andβ-chains are contained in a single open reading frame coding for a pre-pro precursor protein of 728 amino acids, which indicates that the activity of HGF is not species-specific.
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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
Federico Bussolino,M. F. Di Renzo,Marina Ziche,E Bocchietto,Martina Olivero,Luigi Naldini,Giovanni Gaudino,Luca Tamagnone,A Coffer,Paolo M. Comoglio +9 more
TL;DR: Data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate and lacks activities related to hemostasis-thrombosis, inflammation and endothelium cells accessory functions.
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Heparin structure and interactions with basic fibroblast growth factor.
TL;DR: No significant conformational change in bFGF occurred upon heparin oligosaccharide binding, which suggests that heparIn primarily serves to juxtapose components of the FGF signal transduction pathway.
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Scatter factor induces blood vessel formation in vivo.
Derrick S. Grant,Hynda K. Kleinman,Itzhak D. Goldberg,Mahdu M. Bhargava,Brian J. Nickoloff,James L. Kinsella,Peter J. Polverini,Eliot M. Rosen +7 more
TL;DR: Using two different in vivo assays, it is shown that physiologic quantities of purified native mouse scatter factor and recombinant human hepatocyte growth factor induce angiogenesis (the formation of new blood vessels) and that immunoreactive scatter factor is present surrounding sites of blood vessel formation in psoriatic skin.
Scatter factor induces blood vessel formation in vivo (hepatocyte growth factor/angiogenesis/endothelium/psoriasis/plasninogen activator)
Derrick S. Grant,Hynda K. Kleinman,Itzhak D. GOLDBERGt,Mahdu M. BHARGAVAt,J Brian,James L. Kinsella,Peter J. Polverini,Eliot M. Roseni +7 more
TL;DR: This article showed that scatter factor may act as a paracrine mediator in pathologic angio- genesis associated with human inflammatory disease, and immunoreactive scatter factor is present surrounding sites of blood vessel formation in psoriatic skin.