Journal ArticleDOI
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
TLDR
Examination of the distribution of microglia in the normal adult mouse brain using immunocytochemical detection of the macrophage specific plasma membrane glycoprotein F4/80 found no evidence of monocyte-like cells in the adult CNS.About:
This article is published in Neuroscience.The article was published on 1990-01-01. It has received 1810 citations till now. The article focuses on the topics: Neuroglia & Neuropil.read more
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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
TL;DR: Overactivated microglia can be detected using imaging techniques and therefore this knowledge offers an opportunity not only for early diagnosis but, importantly, for the development of targeted anti-inflammatory therapies that might slow or halt the progression of neurodegenerative disease.
Journal ArticleDOI
Physiology of Microglia
TL;DR: Current studies indicate that even in the normal brain, microglia have highly motile processes by which they scan their territorial domains, and microglial cells are considered the most susceptible sensors of brain pathology.
Journal ArticleDOI
Systemic LPS Causes Chronic Neuroinflammation and Progressive Neurodegeneration
Liya Qin,Xuefei Wu,Michelle L. Block,Yuxin Liu,Yuxin Liu,George R. Breese,Jau-Shyong Hong,Darin J. Knapp,Fulton T. Crews +8 more
TL;DR: It is demonstrated that through TNFα, peripheral inflammation in adult animals can activate brain microglia to produce chronically elevated pro‐inflammatory factors and induce delayed and progressive loss of DA neurons in the SN, providing valuable insight into the potential pathogenesis and self‐propelling nature of Parkinson's disease.
Journal ArticleDOI
Microglial physiology: unique stimuli, specialized responses
TL;DR: A wealth of data now demonstrate that the microglia have very diverse effector functions, in line with macrophage populations in other organs, and the term activatedmicroglia needs to be qualified to reflect the distinct and very different states of activation-associated effector function in different disease states.
Journal ArticleDOI
Microglia in neurodegenerative disease
TL;DR: The persistence of activated microglia long after acute injury and in chronic disease suggests that these cells have an innate immune memory of tissue injury and degeneration, and could contribute to the outcome of neurodegenerative diseases.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Periodate-lysine-paraformaldehyde fixative a new fixative for immunoelectron microscopy
Ian W. Mclean,Paul K. Nakane +1 more
TL;DR: Using this fixative and the peroxidase-labeled antibody technique, basement membrane antigen was localized within the cisternae of endoplasmic reticulum of parietal yolk sac cells and in extracellular basement membranes with adequate tissue preservation, a task which has not been successfully accomplished by conventional fixatives.
Journal ArticleDOI
F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Jonathan M. Austyn,Siamon Gordon +1 more
TL;DR: Immunoprecipitation experiments demonstrated that the antigen F4/80 is part of a component of Mr 160000 which is synthesized by the MΦ and, at least in part, exposed on the cell surface.
Journal ArticleDOI
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.
TL;DR: Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived and are fully competent to present antigen to lymphocytes in an appropriately restricted manner.