High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers.
Katharina Grupp,Stella Sanader,Hüseyin Sirma,Ronald Simon,Christina Koop,Kristina Prien,Claudia Hube-Magg,Georg Salomon,Markus Graefen,Hans Heinzer,Sarah Minner,Jakob R. Izbicki,Guido Sauter,Thorsten Schlomm,Maria Christina Tsourlakis +14 more
TLDR
It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision‐making and highlight the potentially important role of lipid metabolism in prostate cancer biology.About:
This article is published in Molecular Oncology.The article was published on 2013-12-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: PCA3 & Lysophosphatidylcholine acyltransferase 1.read more
Citations
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Journal ArticleDOI
Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells
TL;DR: Recent progress in this field contributes to understanding how and why membrane glycerophospholipid diversity is organized and maintained.
Journal ArticleDOI
Phospholipid Remodeling in Physiology and Disease
Bo Wang,Peter Tontonoz +1 more
TL;DR: Mounting evidence suggests that changes in LPCAT activity may be potentially involved in pathological conditions, including nonalcoholic fatty liver disease, atherosclerosis, viral infections, and cancer, and Pharmacological manipulation of L PCAT activity and membrane phospholipid composition may provide new therapeutic options for these conditions.
Journal ArticleDOI
Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study.
Tilman Kühn,Anna Floegel,Disorn Sookthai,Theron Johnson,Ulrike Rolle-Kampczyk,Wolfgang Otto,Martin von Bergen,Martin von Bergen,Heiner Boeing,Rudolf Kaaks +9 more
TL;DR: Changes in blood lipid composition precede the diagnosis of common malignancies by several years and point to a global metabolic shift in phosphatidylcholine metabolism that may drive tumorigenesis.
Journal ArticleDOI
LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway
C. Wei,Xiaomin Dong,Hui Lu,Fan Tong,Lingjuan Chen,Ruiguang Zhang,Ji-Hua Dong,Yu Hu,Gang Wu,Xiaorong Dong +9 more
TL;DR: It is shown that LPCAT1 works as a regulator of cell metastasis and may serve as a novel therapeutic target for BM in lung adenocarcinoma.
Journal ArticleDOI
Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer
Takashi Uehara,Hirotoshi Kikuchi,Shinichiro Miyazaki,Ichirota Iino,Tomohiko Setoguchi,Yoshihiro Hiramatsu,Manabu Ohta,Kinji Kamiya,Yoshifumi Morita,Hiroki Tanaka,Satoshi Baba,Takahiro Hayasaka,Mitsutoshi Setou,Hiroyuki Konno +13 more
TL;DR: Overexpressed LPCAT1 protein in gastric mucosa appears to play important roles in the tumorigenic process of gastric cancer by converting LPC to PC.
References
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TL;DR: Analysis of genomic and clinical outcome data from 218 prostate cancer tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score.
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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
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The genomic complexity of primary human prostate cancer
Michael F. Berger,Michael F. Berger,Michael S. Lawrence,Francesca Demichelis,Yotam Drier,Kristian Cibulskis,Andrey Sivachenko,Andrea Sboner,Raquel Esgueva,Dorothee Pflueger,Carrie Sougnez,Robert C. Onofrio,Scott L. Carter,Kyung Park,Lukas Habegger,Lauren Ambrogio,Timothy Fennell,Melissa Parkin,Gordon Saksena,Douglas Voet,Alex H. Ramos,Alex H. Ramos,Trevor J. Pugh,Trevor J. Pugh,Jane Wilkinson,Sheila Fisher,Wendy Winckler,Scott Mahan,Kristin G. Ardlie,Jennifer Baldwin,Jonathan W. Simons,Naoki Kitabayashi,Theresa Y. MacDonald,Philip W. Kantoff,Lynda Chin,Stacey Gabriel,Mark Gerstein,Todd R. Golub,Todd R. Golub,Todd R. Golub,Matthew Meyerson,Matthew Meyerson,Ashutosh Tewari,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway,Levi A. Garraway +49 more
TL;DR: In this paper, the authors presented the complete sequence of seven primary human prostate cancers and their paired normal counterparts and revealed previously unknown balanced rearrangements, at which multiple intra-and inter-chromosomal loci exchange their breakpoint arms without any loss of genetic material.
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