Journal ArticleDOI
Homoisoflavonoids from Ophiopogon japonicus
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TLDR
In this paper, the root tubers of Ophiopogon japonicus were used for the isolation and identification of 13 homoisoflavonoids, including three new compounds.Abstract:
Phytochemical study on the root tubers of Ophiopogon japonicus resulted in the isolation and identification of 13 homoisoflavonoids, including three new compounds, 8-formyl-7-hydroxy-5,4′-dimethoxy-6-methylhomoisoflavone (1), 6-formylisoophiopogonone B (2), and 8-formylophiopogonanone B (4), and the ten known homoisoflavonoids 3, and 5–13. The absolute configurations of 8-formylophiopogonanone B (4) and 8-formyl-7-hydroxy-5,4′-dimethoxy-6-methylhomoisoflavanone (5) were confirmed by time-dependent density-functional-theory (TD DFT) calculations of their theoretical electronic circular dichroism (ECD) spectra. The structure of the formerly reported ‘6-aldehydoisoophiopogonone B’ was revised to 8-formylophiopogonone B (3). All compounds were evaluated for their cytotoxic activities against the human-lung-tumor A549 cell line, and compounds 3, 9, 10, and 13 exhibited promising antiproliferative activities with IC50 values of 10.01, 6.40, 0.84, and 1.66 μM, respectively.read more
Citations
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Journal ArticleDOI
Ophiopogon japonicus--A phytochemical, ethnomedicinal and pharmacological review.
TL;DR: This review summarizes the achievements of the investigations in botany, phytochemistry, quality control, traditional uses, pharmacological activities and clinical studies on O. japonicus and describes the shortcomings of studies on this herbal drug, which serves as the basis of further scientific research and development of this traditional herbal drug.
Journal ArticleDOI
Naturally occurring homoisoflavonoids and their pharmacological activities.
Ligen Lin,Qian-Yu Liu,Yang Ye +2 more
TL;DR: The main purpose of this review is to provide a comprehensive and up-to-date state of knowledge from phytochemical and pharmacological studies performed on homoisoflavonoids during the past decades.
Journal ArticleDOI
Naturally Occurring Homoisoflavonoids: Phytochemistry, Biological Activities, and Synthesis (Part II):
TL;DR: This review takes note of the recent revision of plant families that were known to contain HIFs that have now been merged into one big family, Asparagaceae, and contains their structures, biological sources, plant parts they are obtained from, and, if reported, their optical rotations and melting points.
Journal ArticleDOI
Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain
Billy T. Tchegnitegni,Rémy Bertrand Teponno,Rémy Bertrand Teponno,Chiaki Tanaka,Adeyemi Francis Gabriel,Léon Azefack Tapondjou,Tomofumi Miyamoto +6 more
TL;DR: Two sappanin-type homoisoflavonoids, (3 R )-7-hydroxy-8-methoxy-3′,4′-methylenedioxyhomoisoflavanone (trifasciatine A) and (3R )-3,7-dihydroxy- 8-mETHoxy- 3′, 4′-methylenedioxhomogenized homogenised homogenized homoogenised homoogeneine (HOMOHA), were isolated as minor components from the
Book ChapterDOI
Homoisoflavonoids: Occurrence, Biosynthesis, and Biological Activity
M.V. Castelli,S.N. López +1 more
TL;DR: This chapter revises the importance of homoisoflavonoids as uncommon scaffolds of natural products, discussing their chemical aspects, biosynthesis, and biological activities by means of a comprehensive analysis of the literature.
References
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Journal ArticleDOI
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
Ligen Lin,Hua Xie,Honglin Li,Linjiang Tong,Chunping Tang,Chang-Qiang Ke,Qun-Fang Liu,Liping Lin,Meiyu Geng,Hualiang Jiang,Wei-Min Zhao,Jian Ding,Yang Ye +12 more
TL;DR: Hematoxylin and its natural analogues were substantially validated to function as a new class of PTK inhibitors and showed good agreement with the result of concurrent molecular docking simulation.
Journal ArticleDOI
Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity.
Tran Manh Hung,Cao Van Thu,Nguyen Tien Dat,Sungwoo Ryoo,Jeong Hyung Lee,Jin-Cheol Kim,MinKyun Na,Hyun-Ju Jung,KiHwan Bae,Byung Sun Min +9 more
TL;DR: Three new homoisoflavonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae) and their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma.
Journal ArticleDOI
Characterization of homoisoflavonoids in different cultivation regions of Ophiopogon japonicus and related antioxidant activity
TL;DR: Hang-maidong had a higher total homoisoflavonoid content and better DPPH (2,2-diphenyl-1-picryl-hydrazyl) radical-scavenging activity than that of Chuan-maidONG, and the total phenolic content showed no significant difference between the two regions.
Journal ArticleDOI
Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler
TL;DR: Compounds 4 and 5 are the first isolated homoisoflavonoids with a hemiacetal function at position 2 and 2,5,7-trihydroxy-6,8-dimethyl-3-(4'-methoxybenzyl)chroman-4-one respectively.