Journal ArticleDOI
Horsfiline, an oxindole alkaloid from Horsfieldia superba
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This article is published in Journal of Organic Chemistry.The article was published on 1991-11-01. It has received 351 citations till now. The article focuses on the topics: Horsfiline & Horsfieldia superba.read more
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Asymmetric domino 1,6-addition/annulation reaction of 3-cyano-4-alkenyl-2H-chromen-2-ones with isatin-derived MBH carbonates: enantioselective synthesis of 3,3′-cyclopentenylspirooxindoles bearing 2H-chromen-2-ones
TL;DR: An asymmetric 1,6-addition/annulation reaction of 3-cyano-4-alkenyl-2H-chromen-2-ones with isatin-derived MBH carbonates was achieved in this article.
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Kharasch-Type Cyclizations of 2-Substituted Indole Derivatives Surprisingly Lead to Spiroindoles
Sarah Van der Jeught,Sarah Van der Jeught,Nils De Vos,Kurt G. R. Masschelein,Ion Ghiviriga,Christian V. Stevens +5 more
TL;DR: In this article, a series of spiro[2-oxoindole-pyrrolidines] was synthesized in a straightforward manner using a Kharasch radical cyclization reaction of trichloroacetylated precursors.
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Molecular hybridization-guided 1,3-dipolar cycloaddition reaction enabled pyrimidine-fused spiropyrrolidine oxindoles synthesis as potential anticancer agents
Xiong-Li Liu,Xiong-Li Liu,Ting-Ting Feng,Wei-Dong Jiang,Chao Yang,Min-Yi Tian,Yan Jiang,Bing Lin,Zhi Zhao,Ying Zhou +9 more
TL;DR: The results demonstrated that most of the compounds showed considerable cytotoxicities to these three cell lines of K562, PC-3, and A549, showed comparably potent or even more potent than the positive control of Cisplatin, and indicated that novel pyrimidine-fused spiropyrrolidine oxindoles may be potential leads for further biological screenings and may generate drug-like molecules.
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An expedient approach for the synthesis of naphthyl dispiro pyrrolidine/pyrrolizidine through 1,3-dipolar cycloaddition reaction
TL;DR: In this paper, the synthesis of naphthyl pyrrolidine/pyrrolizidine-spirooxindoles has been achieved by a one pot three component 1, 3-dipolar cycloaddition (1,3-DC) reaction and the structures and stereochemistry of cycloadducts were confirmed by 1H and 13C NMR spectroscopy, mass spectrometry, and single crystal X-ray diffraction studies.
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Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds.
TL;DR: A diversity-driven three-component 1,3-dipolar cycloaddition of isatins, amino acids and isatin-derived ketimines was developed to facilely assemble dispirooxindole-imidazolidine skeletons bearing vicinal quaternary carbon centers.