Journal ArticleDOI
Horsfiline, an oxindole alkaloid from Horsfieldia superba
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This article is published in Journal of Organic Chemistry.The article was published on 1991-11-01. It has received 351 citations till now. The article focuses on the topics: Horsfiline & Horsfieldia superba.read more
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Organocatalytic Aza-Michael/Michael Cyclization Cascade Reaction: Enantioselective Synthesis of Spiro-oxindole Piperidin-2-one Derivatives.
TL;DR: A simple, direct, and highly enantioselective synthesis of spiro-oxindole piperidin-2-one derivatives was achieved through an aza-Michael/Michael cyclization cascade sequence using a squaramide catalyst.
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Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents
Atul Kumar,Garima Gupta,Suman Srivastava,Ajay Kumar Bishnoi,Ruchi Saxena,Ruchir Kant,Ranjana S. Khanna,Prakas R. Maulik,Anila Dwivedi +8 more
TL;DR: A novel class of diastereoselective spiropyrrolidine-oxindole derivatives were synthesized from isatin, 2-phenylthiazolidine-4-carboxylic acid and chalcone in a one-pot multicomponent reaction via 1,3-dipolar cycloaddition and exhibited promising anti-cancer activity against the human breast cancer cell lines.
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Copper(I) catalyzed diastereoselective multicomponent synthesis of spiroindolo-pyrrolidines/-imidazolidines/-triazolidines from diazoamides via azomethine ylides.
TL;DR: This study demonstrates the successful generation of intermolecular azomethine ylides from copper(I) carbenoids and their subsequent 1,3-dipolar cycloaddition reactions with various dipolarophiles, such as olefins (C=C), imines (N), diazenes (N=N) in a stereoselective manner.
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Novel Spiroheterocycles by Aziridination of α-Methylene-γ- and δ-Lactams
TL;DR: In this article, α-methylene-γ- and -δ-lactams with ethyl N-{[(4-nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO2Et) were prepared by treatment with CaO.
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One‐pot Regioselective Synthesis of Novel 1‐N‐Methyl‐spiro[2,3′]oxindole‐spiro[3,3″]‐1″‐N‐arylpyrrolidine‐2″,5″‐dione‐4‐arylpyrrolidines through Multicomponent 1,3‐Dipolar Cycloaddition Reaction of Azomethine Ylide
TL;DR: An atom economic and facile synthesis of novel dispiro–oxindole–pyrrolidines has been achieved via a three-component tandem cycloaddition of azomethine ylide generated in situ from isatin and sarcosine by decarboxylative condensation with N-aryl-3-benzylidene- pyrrolidine-2,5-dione derivatives as dipolarophiles.