Journal ArticleDOI
How introns enhance gene expression
TLDR
It is suggested that there is no sole, definite answer to the question "how do introns enhance gene expression", rather, each intron-gene combination might undergo its own unique mixture of processes that lead to the perceptible outcome.About:
This article is published in The International Journal of Biochemistry & Cell Biology.The article was published on 2017-10-01. It has received 247 citations till now. The article focuses on the topics: RNA splicing & Minor spliceosome.read more
Citations
More filters
Journal ArticleDOI
Introns as Gene Regulators: A Brick on the Accelerator
TL;DR: The ability of some introns to strongly stimulate mRNA accumulation from several hundred nucleotides downstream of the transcription start site, even when the promoter has been deleted, reveals that the understanding of gene expression remains incomplete.
Journal ArticleDOI
The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology.
TL;DR: This review presents and discusses the pioneering original work as well as the current state-of-the-art research on mammalian NHEs, the solute carrier (SLC) 9 family, and provides a comprehensive view of core knowledge and recent insights into each family member.
Journal ArticleDOI
Genome-wide identification of glutathione S-transferase gene family in pepper, its classification, and expression profiling under different anatomical and environmental conditions
Shiful Islam,Saikat Das Sajib,Zakya Sultana Jui,Shatil Arabia,Tahmina Islam,Ajit Ghosh,Ajit Ghosh +6 more
TL;DR: expression of most of the CaGST transcripts as well as the total pepper GST activity was found to be significantly up-regulated in response to cold, heat, drought, salinity and osmotic stress conditions, which might provide opportunities for future functional validation of this important gene family in pepper.
Journal ArticleDOI
The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture.
Athma A. Pai,Telmo Henriques,Telmo Henriques,Kayla McCue,Adam B. Burkholder,Karen Adelman,Karen Adelman,Christopher B. Burge +7 more
TL;DR: The data suggest that developmental and stress response genes may have preferentially evolved exon definition in order to enhance the rate or accuracy of splicing, and multiple gene level variables associated with splicing rate are identified.
Journal ArticleDOI
Exon-Mediated Activation of Transcription Starts.
TL;DR: Findings support a model in which splicing recruits transcription machinery locally to influence TSS choice and identify exon gain, loss, and regulatory change as major contributors to the evolution of alternative promoters and gene expression in mammals.
References
More filters
Journal ArticleDOI
Pushing the limits of the scanning mechanism for initiation of translation
TL;DR: Examples support the idea that 5′ leader sequences are sometimes structured deliberately in a way that constrains scanning in order to prevent harmful overproduction of potent regulatory proteins.
Journal ArticleDOI
Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4
Michiel Vermeulen,Klaas W. Mulder,Sergei Denissov,W.W.M. Pim Pijnappel,Frederik M. A. van Schaik,Radhika A. Varier,Marijke P. Baltissen,Henk Stunnenberg,Matthias Mann,H. Th. Marc Timmers +9 more
TL;DR: Experiments reveal crosstalk between histone modifications and the transcription factor TFIID, which has important implications for regulation of RNA polymerase II-mediated transcription in higher eukaryotes.
Journal ArticleDOI
Pre-mRNA processing reaches back to transcription and ahead to translation.
TL;DR: This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression.
Journal ArticleDOI
The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
TL;DR: The composition of the exon–exon junction complex is dynamic in vivo and is subject to significant evolution upon mRNA export to the cytoplasm.
Journal ArticleDOI
Introns increase gene expression in cultured maize cells.
TL;DR: It is indicated that introns increase both Adh1 and chimeric gene expression in maize and the optimal location for such an intron is near the 5' end of the mRNA.
Related Papers (5)
BEDTools: a flexible suite of utilities for comparing genomic features
Aaron R. Quinlan,Ira M. Hall +1 more