Journal ArticleDOI
HPLC assisted chemobiological standardization of α-glucosidase-I enzyme inhibitory constituents from Piper longum Linn-An Indian medicinal plant
Srinivas V. Pullela,Ashok Kumar Tiwari,Umamaheswara Sarma Vanka,Anuradha Vummenthula,Hari B. Tatipaka,Krishna Rao Dasari,Ikhlas A. Khan,Madhusudana Rao Janaswamy +7 more
TLDR
A reversed-phase high-performance liquid chromatography method was developed to quantify these active principles in the plant material, which can serve as an effective quality control tool.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2006-12-06. It has received 40 citations till now.read more
Citations
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Journal ArticleDOI
An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice.
Ines Reynoso-Moreno,Israel Najar-Guerrero,Noé Escareño,M.E. Flores-Soto,Jürg Gertsch,Juan Manuel Viveros-Paredes +5 more
TL;DR: Intriguingly, guineensine and LPS independently induced catalepsy, but in combination this effect was abolished, and the described potent pharmacological effects might relate to the reported anti-inflammatory effects of pepper.
CHEMISTRY AND PHARMACOLOGY OF PIPER LONGUM L. Review Article
TL;DR: An attempt has been made to address the chemistry and pharmacology of the plant P. longum, species of the genus Piper belonging to family piperaceae of the unique order piperales of the verticillate of dicotyledones.
Journal Article
Review on the contribution of Ura-Marunnu, a traditional baby care practice in southern India
TL;DR: 1. Post graduate Scholar, Department of PG Studies in Kaumarabhritya, Shri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, India.
Journal ArticleDOI
Two new sesquiterpenoids from the rhizomes of Nardostachys jatamansi
K. Rekha,R. Ranga Rao,Richa Pandey,Kothakonda Rajendra Prasad,Katragadda Suresh Babu,Janakiram R Vangala,Sashi V Kalivendi,Janaswamy Madhusudana Rao +7 more
TL;DR: Phytochemical investigation of CHCl3:MeOH (1:1) extract from the rhizomes of Nardostachys jatamansi led to the isolation of two new sesquiterpenoids (5 and 6), along with six known compounds (1–4, 7, and 8).
Journal ArticleDOI
Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA
Vidadala Rama Subba Rao,Sagi Satyanarayana Raju,V.U.M. Sarma,Fouriner Sabine,Kothapalli Hari Babu,Katragadda Suresh Babu,Janaswamy Madhusudana Rao +6 more
TL;DR: A simple, accurate and precise HPLC-PDA method was developed for the simultaneous determination of the above-mentioned six bioactive compounds and demonstrated that this method is simple, reliable and suitable for the quality control of these plants.
References
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Journal ArticleDOI
Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid.
TL;DR: Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus.
Journal ArticleDOI
Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
Nicole Zitzmann,Anand Mehta,Sandra Carrouee,Terry D. Butters,Frances M. Platt,John W. McCauley,Baruch S. Blumberg,Raymond A. Dwek,Timothy M. Block +8 more
TL;DR: It is shown that in MDBK cells alpha-glucosidase inhibitors prevented the formation and secretion of infectious bovine viral diarrhea virus and data is presented showing that NN-DNJ, compared with NB- DNJ, exhibits a prolonged retention in liver in vivo.
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α-Glucosidase inhibitors as potential broad based anti-viral agents
TL;DR: N‐Linked oligosaccharides play many roles in the fate and functions of glycoproteins and may be useful therapeutics for many viruses, especially those which bud from the endoplasmic reticulum (where protein folding takes place).
Journal ArticleDOI
α-Glucosidase Inhibitors Reduce Dengue Virus Production by Affecting the Initial Steps of Virion Morphogenesis in the Endoplasmic Reticulum
Marie-Pierre Courageot,Marie-Pascale Frenkiel,C. Duarte Dos Santos,Vincent Deubel,Philippe Desprès +4 more
TL;DR: Inhibition of α-glucosidase-mediated N-linked oligosaccharide trimming may prevent the assembly of DEN virus by affecting the early stages of envelope glycoprotein processing.