Journal ArticleDOI
HPLC assisted chemobiological standardization of α-glucosidase-I enzyme inhibitory constituents from Piper longum Linn-An Indian medicinal plant
Srinivas V. Pullela,Ashok Kumar Tiwari,Umamaheswara Sarma Vanka,Anuradha Vummenthula,Hari B. Tatipaka,Krishna Rao Dasari,Ikhlas A. Khan,Madhusudana Rao Janaswamy +7 more
TLDR
A reversed-phase high-performance liquid chromatography method was developed to quantify these active principles in the plant material, which can serve as an effective quality control tool.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2006-12-06. It has received 40 citations till now.read more
Citations
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α-glucosidase inhibitors from plants: A natural approach to treat diabetes.
TL;DR: The present review focuses on constituents isolated from different plants having α-glucosidase inhibitory potency along with IC50 values, which can retard the liberation of d-Glucose from dietary complex carbohydrates and delay glucose absorption, resulting in reduced postprandial plasma glucose levels and suppression of postpr andial hyperglycemia.
Journal ArticleDOI
In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide.
TL;DR: In vivo studies demonstrated that A. paniculata extract significantly reduced peak blood glucose and area under curve in diabetic rats when challenged with oral administration of starch and sucrose, and indicates that AP extract can be considered as a potential candidate for the management of type 2 diabetes mellitus.
Journal ArticleDOI
A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research
TL;DR: Despite traditional claims, insufficient scientific validation for the treatment of insomnia, dementia, epilepsy, rheumatoid arthritis, asthma, spleen disorder, puerperal fever and leprosy, necessitate future investigations in this direction.
Journal ArticleDOI
Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)
Vidadala Rama Subba Rao,Puppala Muthenna,G. Shankaraiah,Chandrasekhar Akileshwari,Kothapalli Hari Babu,Ganji Suresh,Katragadda Suresh Babu,Rotte Sateesh Chandra Kumar,Kothakonda Rajendra Prasad,Potharaju Ashok Yadav,J. Mark Petrash,Geereddy Bhanuprakash Reddy,Janaswamy Madhusudana Rao +12 more
TL;DR: Piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC(50) of 160 μM, and a series of analogues have been synthesized by modification of the styryl/aromatic and heterocyclic ring functionalities of this natural product lead.
Journal ArticleDOI
Novel dimeric amide alkaloids from Piper chaba Hunter: isolation, cytotoxic activity, and their biomimetic synthesis
V. Rama Subba Rao,G. Suresh,K. Suresh Babu,S. Satyanarayana Raju,M.V.P.S. Vishnu Vardhan,Sistla Ramakrishna,J. Madhusudana Rao +6 more
TL;DR: Chabamide H (1), I (2), J (3), K (4) and 11 known compounds were determined on the basis of the comprehensive spectroscopic techniques (IR, Mass, and NMR) as discussed by the authors.
References
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Journal ArticleDOI
Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species
TL;DR: Structural-activity relationships indicate that the N-isobutylamine moiety might play a crucial role in the larvicidal activity, but the methylenedioxyphenyl moiety does not appear essential for toxicity.
Journal ArticleDOI
Study of the Mechanism of Antiviral Action of Iminosugar Derivatives against Bovine Viral Diarrhea Virus
David Durantel,Norica Branza-Nichita,Sandra Carrouée-Durantel,Terry D. Butters,Raymond A. Dwek,Nicole Zitzmann +5 more
TL;DR: It is demonstrated that long-alkyl-chain DNJ and DGJ derivatives induce an increase in the quantity of E2-E2 dimers accumulated within the ER, and exert their antiviral effect solely via the production of viral particles with reduced infectivity.
Journal ArticleDOI
Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking.
Timothy M. Block,Xuanyong Lu,Anand Mehta,Baruch S. Blumberg,Baruch S. Blumberg,Bud C. Tennant,Mathew Ebling,Brent E. Korba,David M. Lansky,Gary S. Jacob,Raymond A. Dwek +10 more
TL;DR: It is provided the first evidence that glucosidase inhibitors can be used in vivo to alter specific steps in the N-linked glycosylation pathway and that this inhibition has anti-viral effects.
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Inhibition of HIV and SIV infectivity by blockade of α-glucosidase activity
TL;DR: Findings demonstrate a critical requirement for oligosaccharide processing by α-glucosidases I and It for HIV-1 and SIVmac envelope processing and fusogenicity and N-BuDNJ had no effect on GAG protein synthesis and processing.
Journal ArticleDOI
Studies on Crude Drugs Effective on Visceral Larva Migrans. IV. : Isolation and Identification of Larvicidal Principles in Pepper
TL;DR: Eight new amide constituents together with seven known amides were isolated from pepper and their structures were determined by spectroscopic means and suggested that the strongest activity was exhibited by the tertiary amides possessing a ninecarbon chain between the aromatic group and the amine moiety.