Journal ArticleDOI
HPLC assisted chemobiological standardization of α-glucosidase-I enzyme inhibitory constituents from Piper longum Linn-An Indian medicinal plant
Srinivas V. Pullela,Ashok Kumar Tiwari,Umamaheswara Sarma Vanka,Anuradha Vummenthula,Hari B. Tatipaka,Krishna Rao Dasari,Ikhlas A. Khan,Madhusudana Rao Janaswamy +7 more
TLDR
A reversed-phase high-performance liquid chromatography method was developed to quantify these active principles in the plant material, which can serve as an effective quality control tool.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2006-12-06. It has received 40 citations till now.read more
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Book ChapterDOI
Advances in Medicinal Plants with Antitumoral Activity
María Pilar Gómez Serranillos Cuadrado,María Teresa Ortega Hernández-Agero,Olga María Palomino Ruiz-Poveda,María Emilia Carretero Accame +3 more
Journal ArticleDOI
The evaluation of normo-glycemic and cyto-regenerative effects of pelargonium species extracts
TL;DR: This research includes data about the anti-inflammatory effect and the rebounding capacity of cells in the presence of two extracts obtained from Pelargonium species, which showed that the hydroalcoholic extract of P. grandiflorum extract showed an improvement in the inflammatory process by about 50% and P. hispidum methanolic Extract showed an anti-oedematous effect of 45% compared to the control.
Journal ArticleDOI
Pharmacological Properties to Pharmacological Insight of Sesamin in Breast Cancer Treatment: A Literature-Based Review Study
Md.Ferdaus Alam Sohel,Md. Nurul Islam,Md. Arju Hossain,Tayeba Sultana,Amitsankar Dutta,Sohanur Rahman,Suraiya Aktar,Kh. Nurul Islam,Abdullah Al Mamun +8 more
TL;DR: It is summarized that this phytoestrogen suppressed NF-κB, STAT, MAPK, and PIK/AKT signaling pathways and activated some tumor suppressor protein in numerous breast cancer models and exhibited promising pharmacokinetics properties with less toxicity in the bodies.
References
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Journal ArticleDOI
Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid.
TL;DR: Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus.
Journal ArticleDOI
Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
Nicole Zitzmann,Anand Mehta,Sandra Carrouee,Terry D. Butters,Frances M. Platt,John W. McCauley,Baruch S. Blumberg,Raymond A. Dwek,Timothy M. Block +8 more
TL;DR: It is shown that in MDBK cells alpha-glucosidase inhibitors prevented the formation and secretion of infectious bovine viral diarrhea virus and data is presented showing that NN-DNJ, compared with NB- DNJ, exhibits a prolonged retention in liver in vivo.
Journal ArticleDOI
α-Glucosidase inhibitors as potential broad based anti-viral agents
TL;DR: N‐Linked oligosaccharides play many roles in the fate and functions of glycoproteins and may be useful therapeutics for many viruses, especially those which bud from the endoplasmic reticulum (where protein folding takes place).
Journal ArticleDOI
α-Glucosidase Inhibitors Reduce Dengue Virus Production by Affecting the Initial Steps of Virion Morphogenesis in the Endoplasmic Reticulum
Marie-Pierre Courageot,Marie-Pascale Frenkiel,C. Duarte Dos Santos,Vincent Deubel,Philippe Desprès +4 more
TL;DR: Inhibition of α-glucosidase-mediated N-linked oligosaccharide trimming may prevent the assembly of DEN virus by affecting the early stages of envelope glycoprotein processing.