Journal ArticleDOI
Human cardiac troponin complex. Structure and functions
TLDR
This review summarizes the existing evidence on the structure and function of troponin complex subunits, their role in the regulation of cardiac muscle contraction, and their clinical applications.Abstract:
Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of three subunits — troponin I, T, and C, and it plays a crucial role in muscle activity, connecting changes in intracellular Ca2+ concentration with generation of contraction. In spite of more than 40 years of studies, many aspects of troponin functioning are still not completely understood, and several models describing the mechanism of muscle contraction exist. Being a key factor in the regulation of cardiac muscle contraction, troponin complex is utilized in medicine as a target for some cardiotonic drugs used in the treatment of heart failure. A number of mutations in troponin subunits are associated with development of different types of cardiomyopathy. Moreover, for the last 25 years cardiac isoforms of troponin I and T have been widely used for immunochemical diagnostics of pathologies associated with cardiomyocyte death (myocardial infarction, myocardial trauma, and others). This review summarizes the existing evidence on the structure and function of troponin complex subunits, their role in the regulation of cardiac muscle contraction, and their clinical applications.read more
Citations
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Journal ArticleDOI
How is cardiac troponin released from injured myocardium
Johannes Mair,Bertil Lindahl,Ola Hammarsten,Christian Müller,Evangelos Giannitsis,Kurt Huber,Martin Möckel,Mario Plebani,Kristian Thygesen,Allan S. Jaffe +9 more
TL;DR: The comparably lower sensitivities of all currently available imaging modalities, including cardiac magnetic resonance imaging for the detection of particularly non-focal myocardial necrosis in patients, has to be considered for cardiac troponin test result interpretation in clinical settings without any other evidence for myocardia necrosis apart from increased cardiac trop onin concentrations.
OtherDOI
Overview of the Muscle Cytoskeleton.
TL;DR: In this review, the components of striated muscle are highlighted with respect to their interactions, signaling pathways, functions, and connections to disease.
Journal ArticleDOI
Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos
Junchao Duan,Yang Yu,Yang Li,Yanbo Li,Hongcui Liu,Li Jing,Man Yang,Ji Wang,Chunqi Li,Zhiwei Sun +9 more
TL;DR: For the first time, it is demonstrated that SiNPs induced cardiac dysfunction via the neutrophil-mediated cardiac inflammation and cardiac contraction in zebrafish embryos.
Journal ArticleDOI
High sensitivity cardiac troponin assays in the clinical laboratories
TL;DR: It is envisaged that the high sensitivity assays will become important tools for predicting each patient’s risk of future adverse events and for guiding and monitoring corresponding adjustments of preventative therapeutic interventions.
Journal ArticleDOI
Comparison Between High-Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort
Paul Welsh,David Preiss,Anoop S V Shah,David A. McAllister,Andrew Briggs,Charles Boachie,Alex McConnachie,Caroline Hayward,Sandosh Padmanabhan,Claire E. Welsh,Mark Woodward,Mark Woodward,Archie Campbell,David J. Porteous,Nicholas L. Mills,Naveed Sattar +15 more
TL;DR: In the general population, cTNT and cTnI concentrations are weakly correlated and are differentially associated with cardiovascular risk factors.
References
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Journal ArticleDOI
Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases
Perry M. Elliott,Bert Andersson,Eloisa Arbustini,Zofia T. Bilińska,Franco Cecchi,Philippe Charron,Olivier Dubourg,Uwe Kühl,Bernhard Maisch,William J. McKenna,Lorenzo Monserrat,Sabine Pankuweit,Claudio Rapezzi,Petar M. Seferović,Luigi Tavazzi,Andre Keren +15 more
TL;DR: This document, The European Society of Cardiology Working Group on Myocardial and Pericardial Diseases presents an update of the existing classification scheme, to help clinicians look beyond generic diagnostic labels in order to reach more specific diagnoses.
Journal ArticleDOI
Regulation of Contraction in Striated Muscle
TL;DR: Ca(2+) regulation of contraction in vertebrate striated muscle is exerted primarily through effects on the thin filament, which regulate strong cross-bridge binding to actin, and the physiological observations of steady-state and transient mechanical behavior are supported.
Journal ArticleDOI
Atomic model of the actin filament
TL;DR: A unique orientation of the monomer with respect to the actin helix has been found and the main interactions are along the two-start helix with a contribution from a loop extending across the filament axis provided by the molecule in the adjacent strand.
Journal ArticleDOI
Early diagnosis of myocardial infarction with sensitive cardiac troponin assays.
Tobias Reichlin,Willibald Hochholzer,Stefano Bassetti,Stefano Bassetti,Stephan Steuer,Claudia Stelzig,Sabine Hartwiger,Stefan Biedert,Nora Schaub,Christine Buerge,Mihael Potocki,Markus Noveanu,Tobias Breidthardt,Raphael Twerenbold,Katrin Winkler,Roland Bingisser,Christian Mueller +16 more
TL;DR: The diagnostic performance of sensitive cardiac troponin assays is excellent, and these assays can substantially improve the early diagnosis of acute myocardial infarction, particularly in patients with a recent onset of chest pain.
Journal ArticleDOI
Structure and evolution of calcium-modulated proteins.
TL;DR: The intracellular functions of calcium are best understood in terms of calcium's functioning as a second messenger, and this line of thought leads to a suggestion of the evolutionary reason for the choice of calcium as the sole inorganic second messenger.
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