Journal ArticleDOI
Human serum albumin (HSA) nanoparticles: Reproducibility of preparation process and kinetics of enzymatic degradation
Klaus Langer,Marion G. Anhorn,Isabel Steinhauser,Sebastian Dreis,D. Celebi,N. Schrickel,S. Faust,Vitali Vogel +7 more
TLDR
It could be shown that the kinetics of particle degradation was dependent on the degree of particle stabilisation, which will influence drug release after cellular accumulation of HSA nanoparticles.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2008-01-22. It has received 208 citations till now. The article focuses on the topics: Human serum albumin & Serum albumin.read more
Citations
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Journal ArticleDOI
Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.
TL;DR: In this review, state-of-the-art nanoparticles and targeted systems that have been investigated in clinical studies are discussed and the challenges faced in using nanomedicine products and translating them from a preclinical level to the clinical setting are emphasized.
Journal ArticleDOI
Albumin-based nanoparticles as potential controlled release drug delivery systems.
TL;DR: The current review embodies an in-depth discussion of albumin nanoparticles with respect to types, formulation aspects, major outcomes of in vitro and in vivo investigations as well as site-specific drug targeting using various ligands modifying the surface of albumins with special insights to the field of oncology.
Journal ArticleDOI
Protein-based nanocarriers as promising drug and gene delivery systems
TL;DR: The current review highlights the main advances achieved in utilizing protein nanocarriers as natural vehicles for drug and gene delivery tasks with respect to types, advantages, limitations, formulation aspects as well as the major outcomes of the in vitro and in vivo investigations.
Journal ArticleDOI
Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy
TL;DR: This paper reviews the most significant advancements in protein nanoparticle technology and their use in drug delivery arena, and examines the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation.
References
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Journal ArticleDOI
Atomic structure and chemistry of human serum albumin.
Xiao Min He,Daniel C. Carter +1 more
TL;DR: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 Å and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serumalbumin.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Book ChapterDOI
Structure of serum albumin.
Daniel C. Carter,Joseph X. Ho +1 more
TL;DR: This chapter provides an insight of the findings of past significant papers with the current knowledge of the recently determined high resolution X-ray structure of serum albumin and suggests that AFP may have a higher affinity for some unknown ligands important for fetal development.
Journal ArticleDOI
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
William J. Gradishar,Sergei Tjulandin,Neville Davidson,Heather S. Shaw,Neil Desai,P. Bhar,Michael M. Hawkins,Joyce O'Shaughnessy +7 more
TL;DR: The improved therapeutic index and elimination of corticosteroid premedication required for solvent-based taxanes make the novel albumin-bound paclitaxel ABI-007 an important advance in the treatment of MBC.