Journal ArticleDOI
Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: Distribution in a human/hamster hybrid cell
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TLDR
The first example of a predominantly nuclear protein which during mitosis becomes part of the mitotic apparatus is described and the results suggest that the human gene coding for NuMA protein, unlike other genes coding for human specific nuclear proteins, can be expressed in human/hamster hybrid cells and that the cell hybrids will be useful in further characterization of NuMAprotein.About:
This article is published in Cell.The article was published on 1980-11-01. It has received 242 citations till now. The article focuses on the topics: Nuclear protein & Mitosis.read more
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Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
Ari Melnick,Jonathan D. Licht +1 more
TL;DR: The elucidation of the molecular basis of acute promyelocytic leukemia emerged as a paradigm for the connection between the bench and bedside and it became apparent that APL was, among the forms of acute myeloid leukemia, uniquely sensitive to all
Journal ArticleDOI
Macromolecular domains within the cell nucleus.
TL;DR: A chronology of key events and events leading to the formation of the HJ-Uridine Incorporation, In Situ Nick Translation, and subsequent efforts to correct for these errors.
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A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle Assembly
TL;DR: It is suggested that NuMA forms bifunctional complexes with cytoplasmic dynein and dynactin that can tether microtubules at the spindle poles and that are essential for mitotic spindle pole assembly and stabilization.
Journal Article
Nuclear matrix: Isolation and characterization of a framework structure from rat liver nuclei
Ronald Berezney,Donald S. Coffey +1 more
TL;DR: A nuclear matrix structure termed the nuclear matrix has been isolated and characterized in this article, which consists largely of protein with smaller amounts of RNA, DNA, carbohydrate, and phospholipid.
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Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly
Maxence V. Nachury,Thomas J. Maresca,Wendy C. Salmon,Clare M. Waterman-Storer,Rebecca Heald,Karsten Weis +5 more
TL;DR: It is shown that the mitotic role of Ran is largely mediated by the nuclear transport factor importin β, and it is proposed that RanGTP functions in mitosis as in interphase by locally releasing cargoes from transport factors.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
TL;DR: The present study arose from the observation that a more intense colour was sometimes produced if, instead of being heated at 1000 for 10 min., the reaction mixture was allowed to stand overnight at room temperature.