Journal ArticleDOI
Hydroxylation of aromatic hydrocarbons in the rat
Olav M. Bakke,Ronald R. Scheline +1 more
TLDR
The hydroxylation of benzene, toluene, ethylbenzene, styrene, cumene, o -xylene, m -xylene, p -Xylene, p-cymene, pseudocumene, and mesitylene was studied following their oral administration to rats to study the formation of phenolic metabolites to the toxicity of aromatic hydrocarbons.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-05-01. It has received 164 citations till now. The article focuses on the topics: Xylene & Ethylbenzene.read more
Citations
More filters
Journal ArticleDOI
Studies on metabolism and toxicity of styrene. V. The metabolism of styrene, racemic, (R)-(+)-, and (S)-(--)-phenyloxiranes in the rat.
TL;DR: A remarkable stereoselectivity was observed in the excretion of both types of the metabolites when optically active phenyloxiranes were administered and the most significant regioisomeric mercapturic acids in theexcretion of MA's was observed when styrene and (S)-phenylxirane were administered.
Journal ArticleDOI
Dog liver microsomal P450 enzyme-mediated toluene biotransformation
TL;DR: The results suggested that the P4502B, 2C and 2E isozymes in dog liver contribute to the formation of benzyl alcohol and p-cresol from toluene, and2E isozyme preferentially contributes to theformation of o-c Resol.
Journal ArticleDOI
Metabolism and Toxicity of the Styrene Metabolite 4-Vinylphenol in CYP2E1 Knockout Mice
TL;DR: The data suggest that, as for styrene, additional cytochromes P-450 are involved in the metabolism of 4-VP, and further elucidate the possible role in styrene-induced toxicity and the importance of its metabolism by CYP2E1.
Journal ArticleDOI
Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons.
TL;DR: The results give further insight into the stereotoxicity of styrene in man and the close structural relation of these metabolites to the primarily formed epoxide.
Journal ArticleDOI
Analysis of urinary biomarkers for exposure to alkyl benzenes by isotope dilution gas chromatography-mass spectrometry.
TL;DR: A validated GC-MS method for the analysis of urinary metabolites of alkyl benzenes is reported and pentafluorobenzyl derivatives were found to be sufficiently stable for overnight batch analysis.
References
More filters
Journal ArticleDOI
Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents.
TL;DR: Rat caecal contents decarboxylate phenolic benzoic acid derivatives when a free hydroxyl group is in the para position but the presence of substituents adjacent to this group or the carboxyl group reduce or abolish the reaction.
Journal ArticleDOI
Kinetic studies of the metabolism of foreign organic compounds. 1. The formation of benzoic acid from benzamide, toluene, benzyl alcohol and benzaldehyde and its conjugation with glycine and glucuronic acid in the rabbit
H. G. Bray,W. V. Thorpe,K. White +2 more