Journal ArticleDOI
Hydroxylation of aromatic hydrocarbons in the rat
Olav M. Bakke,Ronald R. Scheline +1 more
TLDR
The hydroxylation of benzene, toluene, ethylbenzene, styrene, cumene, o -xylene, m -xylene, p -Xylene, p-cymene, pseudocumene, and mesitylene was studied following their oral administration to rats to study the formation of phenolic metabolites to the toxicity of aromatic hydrocarbons.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-05-01. It has received 164 citations till now. The article focuses on the topics: Xylene & Ethylbenzene.read more
Citations
More filters
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission, Flavouring Group Evaluation 22: Ring-substituted phenolic substances from chemical groups 21 and 25: Question No EFSA-Q-2003-165
John Christian Larsen,Karin Kristiane Nørby,Trine Klein Reffstrup,Vibe Meister Beltoft,Henrik Lauritz Frandsen +4 more
TL;DR: The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States as mentioned in this paper.
Journal ArticleDOI
Review of the toxicology of styrene.
TL;DR: Needed areas of future research on styrene include studies on the molecular dosimetry of styrene in terms of both hemoglobin and DNA adducts, which should improve the ability to assess the relationship between exposure to styrene and surrogate measures of "effective dose", thereby improving the able to estimate the effects of low-level human exposures.
Journal ArticleDOI
Metabolism and toxicity of styrene.
TL;DR: Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.
Journal ArticleDOI
An overview of environmental and toxicological aspects of aromatic hydrocarbons. I. Benzene.
TL;DR: Xylenes are an agent of major chemical and occupational significance and is extensively employed in a broad spectrum of applications, primarily as a solvent for which its use is increasing as a "safe" replacement for benzene, and in gasoline as part of the BTX component.
Journal ArticleDOI
Accumulation and metabolism of carbon-14 labeled benzene, naphthalene, and anthracene by young coho salmon (Oncorhynchus kisutch)
TL;DR: The findings indicated that the aromatic hydrocarbons in key organs increased in relation to the number of benzenoid rings, and it appears that aromatic metabolites are broadly distributed throughout fish exposed to polynuclear aromatic Hydrocarbons.
References
More filters
Journal ArticleDOI
Studies in detoxication. 56. The metabolism of alkylbenzenes: stereochemical aspects of the biological hydroxylation of ethylbenzene to methylphenylcarbinol.
Journal ArticleDOI
Metabolism of derivatives of toluene. 3. o-, m- and p-xylenes.
Journal ArticleDOI
Zur Kenntnis des Verhaltens fettaromatischer Ketone im Tierkörper.
H. Thierfelder,K. Daiber +1 more
Journal ArticleDOI
Analysis of simple phenols of interest in metabolism: II. Conjugate hydrolysis and extraction methods
Olav M. Bakke,Ronald R. Scheline +1 more
TL;DR: Methods for conjugate hydrolysis and ether extraction of simple phenols in urine have been investigated and recoveries of some dihydroxybenzenes were considerably reduced and these losses were shown to occur during the removal of phenolic acids.