Journal ArticleDOI
Hydroxylation of aromatic hydrocarbons in the rat
Olav M. Bakke,Ronald R. Scheline +1 more
TLDR
The hydroxylation of benzene, toluene, ethylbenzene, styrene, cumene, o -xylene, m -xylene, p -Xylene, p-cymene, pseudocumene, and mesitylene was studied following their oral administration to rats to study the formation of phenolic metabolites to the toxicity of aromatic hydrocarbons.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-05-01. It has received 164 citations till now. The article focuses on the topics: Xylene & Ethylbenzene.read more
Citations
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Journal ArticleDOI
New urinary metabolites formed from ring-oxidized metabolic intermediates of styrene.
Igor Linhart,Jaroslav Mráz,Jan Scharff,Jan Krouzelka,Šárka Dušková,Hana Nohová,Ludmila Vodickova +6 more
TL;DR: Findings indicate a capability of 3,4-STO to react with cellular thiol groups despite its rapid isomerization to vinylphenol in an aqueous environment.
Journal ArticleDOI
Effects of soil on percutaneous absorption of toluene in male rats.
TL;DR: Pure and soil-adsorbed toluene were primarily metabolized and excreted via the kidney rather than exhaled, and soil treatment did not alter the percentages of the metabolic products.
Journal ArticleDOI
Metabolites of (+)-dehydroabietic acid in rabbits
TL;DR: The seven metabolites of (+)-dehydroabietic acid (DHA) were newly isolated from rabbit urine by liquid chromatography and on the basis of chemical and spectral data their structures were established to be (15S)-8,11.
Journal ArticleDOI
The role of glutathione and cysteine conjugates in the nephrotoxicity of o-xylene in rats.
TL;DR: The data obtained suggest that the glutathione pathway would appear to be only detoxication, and probably does not contribute to the renal toxicity of o-xylene in female rats.
Journal ArticleDOI
Cytogenetic evaluation of bone marrow cells from rats exposed to styrene vapor for one year
Anil K. Sinha,George C. Jersey,Virginia A. Linscombe,Rebecca L. Adams,Anne M. Mueller,Mary L. McClintock +5 more
TL;DR: It is interpreted that styrene is non-clastogenic within the present exposure regimen and neither the 600 ppm nor the 1000 ppm exposures to styrene vapor produced an incidence of chromosomal anomalies higher than those occurring spontaneously.
References
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Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents.
TL;DR: Rat caecal contents decarboxylate phenolic benzoic acid derivatives when a free hydroxyl group is in the para position but the presence of substituents adjacent to this group or the carboxyl group reduce or abolish the reaction.
Journal ArticleDOI
Kinetic studies of the metabolism of foreign organic compounds. 1. The formation of benzoic acid from benzamide, toluene, benzyl alcohol and benzaldehyde and its conjugation with glycine and glucuronic acid in the rabbit
H. G. Bray,W. V. Thorpe,K. White +2 more