Journal ArticleDOI
Hydroxylation of aromatic hydrocarbons in the rat
Olav M. Bakke,Ronald R. Scheline +1 more
TLDR
The hydroxylation of benzene, toluene, ethylbenzene, styrene, cumene, o -xylene, m -xylene, p -Xylene, p-cymene, pseudocumene, and mesitylene was studied following their oral administration to rats to study the formation of phenolic metabolites to the toxicity of aromatic hydrocarbons.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-05-01. It has received 164 citations till now. The article focuses on the topics: Xylene & Ethylbenzene.read more
Citations
More filters
Journal ArticleDOI
Effect of the inhibition of the metabolism of 4-vinylphenol on its hepatotoxicity and pneumotoxicity in rats and mice.
TL;DR: Inhibition of these cytochromes P450 with either diethyldithiocarbamate or 5-phenyl-1-pentyne as inhibitors of CYP2E1 and CYP1F2 prevented or greatly decreased the hepatotoxicity of 4-VP and its pneumotoxicity are due to a metabolite(s) and not the parent compound.
Journal ArticleDOI
Relationship between uptake and elimination of toluene and debrisoquin hydroxylation polymorphism.
TL;DR: There were no significant differences between the two phenotypic groups with regard to concentration of toLUene in blood, apparent blood clearance of toluene, or excretion of hippuric acid and o‐cresol.
Journal ArticleDOI
Disposition of [Ring-U-14C]styrene in Rats and Mice Exposed by Recirculating Nose-Only Inhalation
TL;DR: The larger production of (14)CO(2) might be indicative of the formation of reactive ring-opened metabolites in the mouse lung, which, in turn, might be related to the observed development of bronchioalveolar tumors and nasal effects in mice exposed to styrene.
Journal ArticleDOI
Acidic metabolites of pseudocumene in rabbit urine.
TL;DR: In order to identify biological indicators of exposure to trimethylbenzenes, the metabolism of pseudocumene was investigated in rabbits and two major urinary metabolites were identified, namely 2,4-dimethylbenzoic acid and 3,4,dimethylhippuric acid.
Journal ArticleDOI
Shaping of the 3D genome by the ATPase machine cohesin.
Yoori Kim,Hongtao Yu,Hongtao Yu +2 more
TL;DR: The current understanding of interphase genome organization is reviewed with a focus on the major regulator of genome structure, the cohesin complex, and how cohesIn harnesses the energy of ATP hydrolysis to shape the genome by extruding chromatin loops.
References
More filters
Journal ArticleDOI
Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents.
TL;DR: Rat caecal contents decarboxylate phenolic benzoic acid derivatives when a free hydroxyl group is in the para position but the presence of substituents adjacent to this group or the carboxyl group reduce or abolish the reaction.
Journal ArticleDOI
Kinetic studies of the metabolism of foreign organic compounds. 1. The formation of benzoic acid from benzamide, toluene, benzyl alcohol and benzaldehyde and its conjugation with glycine and glucuronic acid in the rabbit
H. G. Bray,W. V. Thorpe,K. White +2 more