Journal ArticleDOI
Hydroxylation of aromatic hydrocarbons in the rat
Olav M. Bakke,Ronald R. Scheline +1 more
TLDR
The hydroxylation of benzene, toluene, ethylbenzene, styrene, cumene, o -xylene, m -xylene, p -Xylene, p-cymene, pseudocumene, and mesitylene was studied following their oral administration to rats to study the formation of phenolic metabolites to the toxicity of aromatic hydrocarbons.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1970-05-01. It has received 164 citations till now. The article focuses on the topics: Xylene & Ethylbenzene.read more
Citations
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Ultraviolet-absorbing compounds in milk are related to forage polyphenols.
Jean-Michel Besle,Didier Viala,Bruno Martin,P. Pradel,Bruno Meunier,J. L. Berdague,D. Fraisse,J. L. Lamaison,Jean-Baptiste Coulon +8 more
TL;DR: Ultraviolet-absorbing compounds in milk are a potential tool to distinguish between milks according to diet and may have a bioactive effect on milk component conservation or on human health.
Journal ArticleDOI
Toluene-induced oxidative stress in several brain regions and other organs.
TL;DR: Exposure to toLUene results in broad systemic elevation in the normal rate of oxygen radical generation, with such effects persisting in the tissues despite a rapid decline in toluene blood levels, demonstrating that acute exposure to toLuene may lead to extended ROS-related changes, and this may account for some of the clinical observations made in chronic toluenes abusers.
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Effects of xylene and xylene isomers on cytochrome P-450 and in vitro enzymatic activities in rat liver, kidney and lung
Rune Toftgård,Odd G. Nilsen +1 more
TL;DR: The ability of xylene and xylene isomers to modify the metabolism of other potentially toxic substances in liver, kidney and lung microsomes suggests the possibility of synergistic toxic responses.
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Xenobiotic metabolism and the mechanism(s) of benzene toxicity.
TL;DR: Studies of benzene metabolism have delineated the array of metabolites which appear to play a role in bone marrow damage, but further studies, both in vivo and in vitro, using appropriate animal models will be needed to fully understand the impact of Benzene and its metabolites on bone marrow function.
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Chromosomal aberrations and sister-chromatid exchanges in lymphocytes of men occupationally exposed to styrene in a plastic-boat factory
TL;DR: Blood samples were taken in 1978 from workers belonging to the exposed groups and from a matched control group of employees in the same factory not exposed to styrene, but multiple regression analysis failed to show a candidate responsible for the increase in chromosomal abnormalities in the exposed group.
References
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Journal ArticleDOI
Decarboxylation and demethylation of some phenolic benzoic acid derivatives by rat caecal contents.
TL;DR: Rat caecal contents decarboxylate phenolic benzoic acid derivatives when a free hydroxyl group is in the para position but the presence of substituents adjacent to this group or the carboxyl group reduce or abolish the reaction.
Journal ArticleDOI
Kinetic studies of the metabolism of foreign organic compounds. 1. The formation of benzoic acid from benzamide, toluene, benzyl alcohol and benzaldehyde and its conjugation with glycine and glucuronic acid in the rabbit
H. G. Bray,W. V. Thorpe,K. White +2 more