Journal ArticleDOI
Hypertension in people living with HIV.
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TLDR
The burden of hypertension among people living with HIV is high and its pathophysiology most likely multifactorial, and efforts should be made to improve hypertension management as per existing clinical guidelines in order to safeguard cardiovascular health and quality of life in PLHIV.Abstract:
Purpose of reviewThis review describes what is known concerning the burden of hypertension among people living with HIV (PLHIV), and also addresses relevant topics with respect to its risk factors and clinical management.Recent findingsHypertension is highly prevalent in HIV-positive populations, anread more
Citations
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Journal ArticleDOI
Hypertension in HIV-Infected Adults: Novel Pathophysiologic Mechanisms.
TL;DR: The mechanisms of hypertension in HIV infection are explored, which are critical to public health efforts to prevent hypertension, cardiovascular disease and premature mortality in HIV-infected adults.
Journal ArticleDOI
Vascular cognitive impairment and HIV-associated neurocognitive disorder: a new paradigm
Lucette A. Cysique,Bruce J. Brew +1 more
TL;DR: The probable total burden of VCI in the global HIV population is higher than in the general population and would need to be compared to chronic conditions such as type I diabetes and multiple sclerosis to account for the disease chronicity and lifelong treatment effects.
Journal ArticleDOI
Patho-immune Mechanisms of Hypertension in HIV: a Systematic and Thematic Review
Sepiso K. Masenga,Sepiso K. Masenga,Sepiso K. Masenga,Benson M. Hamooya,Benson M. Hamooya,Selestine Nzala,Geoffrey Kwenda,Douglas C. Heimburger,Wilbroad Mutale,Sody Munsaka,John R. Koethe,Annet Kirabo,Annet Kirabo +12 more
TL;DR: Comparing studies from Sub-Saharan Africa with what is reported in the USA and European literature on the role of immune cell activation in the pathogenesis of hypertension in people living with HIV is compared.
Journal ArticleDOI
Integrated Hypertension and HIV Care Cascades in an HIV Treatment Program in Eastern Uganda: A Retrospective Cohort Study.
Martin Muddu,Andrew K. Tusubira,Srish Sharma,Ann R. Akiteng,Isaac Ssinabulya,Jeremy I. Schwartz +5 more
TL;DR: The HIV care cascade approached global targets, while the parallel HTN care cascade demonstrated notable quality gaps, suggesting that models of integration should focus on screening PLHIV for HTN and retention and control of those diagnosed to fully leverage the successes of HIV programs.
Journal ArticleDOI
Predictive Performance of Cardiovascular Disease Risk Prediction Algorithms in People Living With HIV.
Rosan A van Zoest,Rosan A van Zoest,Matthew Law,Caroline A. Sabin,Ilonca Vaartjes,Marc van der Valk,Joop E Arends,Peter Reiss,Ferdinand W. N. M. Wit +8 more
TL;DR: All algorithms perform reasonably well in PLWH, with SCORE-NL performing poorest and prediction algorithms are useful for clinical practice, but clinicians should be aware of their limitations.
References
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Journal ArticleDOI
Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease.
TL;DR: AMI rates and cardiovascular risk factors were increased in HIV compared with non-HIV patients, particularly among women, and cardiac risk modification strategies are important for the long-term care of HIV patients.
Journal ArticleDOI
HIV Infection and the Risk of Acute Myocardial Infarction
Matthew S. Freiberg,Chung-Chou H. Chang,Lewis H. Kuller,Melissa Skanderson,Elliott Lowy,Kevin L. Kraemer,Adeel A. Butt,Matthew Bidwell Goetz,David A. Leaf,Krisann K. Oursler,David Rimland,Maria C. Rodriguez Barradas,Sheldon T. Brown,Cynthia Gibert,Kathy McGinnis,Kristina Crothers,Jason J. Sico,Heidi M. Crane,Alberta L. Warner,Stephen S. Gottlieb,John S. Gottdiener,Russell P. Tracy,Matthew J. Budoff,Courtney Watson,Kaku A. Armah,Donna Almario Doebler,Kendall Bryant,Amy C. Justice +27 more
TL;DR: Investigating whether HIV is associated with an increased risk of acute myocardial infarction after adjustment for all standard Framingham risk factors among a large cohort of HIV-positive and demographically and behaviorally similar uninfected veterans in care found infections with HIV are associated with a 50% increased risk beyond that explained by recognized risk factors.
Journal ArticleDOI
Cardiovascular disease risk factors in HIV patients - association with antiretroviral therapy. Results from the DAD study
Nina Friis-Møller,Rainer Weber,Peter Reiss,Rodolphe Thiébaut,Ole Kirk,Antonella d'Arminio Monforte,Christian Pradier,Linda Morfeldt,Silvia Mateu,Mathew M.G. Law,Wafaa El-Sadr,Stéphane De Wit,Caroline A. Sabin,Andrew N. Phillips,Jens D Lundgren +14 more
TL;DR: Of specific concern is the fact that use of the NNRTI and PI drug classes (alone and especially in combination), particularly among older subjects with normalized CD4 cell counts and suppressed HIV replication, was associated with a lipid profile known to increase the risk of coronary heart disease.
Journal ArticleDOI
Inflammation, Immunity, and Hypertension
David G. Harrison,Tomasz J. Guzik,Heinrich E. Lob,Meena S. Madhur,Paul J. Marvar,Salim R. Thabet,Antony Vinh,Cornelia M. Weyand +7 more
TL;DR: Components of the innate and adaptive immune response are reviewed, data from many groups are discussed that suggest that common forms of hypertension are immune mediated, and a working hypothesis of how signals from the central nervous system trigger an immune response that causes hypertension is provided.
Journal ArticleDOI
Future challenges for clinical care of an ageing population infected with HIV: a modelling study
Mikaela Smit,Kees Brinkman,Suzanne E. Geerlings,Colette Smit,Kalyani Thyagarajan,Ard van Sighem,Frank de Wolf,Timothy B. Hallett +7 more
TL;DR: The profile of patients in the Netherlands infected with HIV is changing, with increasing numbers of older patients with multiple morbidities, which means that, in the near future, HIV care will increasingly need to draw on a wide range of medical disciplines, in addition to evidence-based screening and monitoring protocols to ensure continued high-quality care.
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