Journal ArticleDOI
IBD immunopathogenesis: A comprehensive review of inflammatory molecules.
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TLDR
The roles of numerous inflammatory molecules including but not limited to cytokines, chemokines, inflammasomes, microRNAs and neuropeptides and their expression status in ulcerative colitis and Crohn's disease are discussed in relation to their effects on the overall intestinal inflammatory process.About:
This article is published in Autoimmunity Reviews.The article was published on 2017-04-01. It has received 207 citations till now. The article focuses on the topics: Inflammatory bowel disease & Ulcerative colitis.read more
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Dampening inflammation by modulating tlr signalling
TL;DR: In this paper, the authors explore the current knowledge about distinct signalling cascades resulting from self TLR activation and highlight the involvement of endogenous TLR activators in disease and highlight how specifically targeting DAMPs may yield therapies that do not globally suppress the immune system.
Journal ArticleDOI
TSLP Promotes Interleukin-3-independent Basophil Haematopoiesis and Type 2 Inflammation
TL;DR: This study determined how TSLP contributes to allergic disease pathogenesis by performing studies in mice and human studies with the use of basophils from patients with eosinophilic esophagitis or from healthy controls.
Journal ArticleDOI
JAK inhibitors for the treatment of autoimmune and inflammatory diseases
Yvan Jamilloux,Thomas El Jammal,Lucine Vuitton,Mathieu Gerfaud-Valentin,Sébastien Kerever,Pascal Sève +5 more
TL;DR: This extensive review of JAK inhibitors presents evidence- or hypothesis-based perspectives for these drugs in various rheumatologic conditions, such as r heumatoid arthritis, systemic lupus erythematosus, giant cell arteritis, and autoinflammatory diseases.
Journal ArticleDOI
Physical activity and autoimmune diseases: Get moving and manage the disease
Kassem Sharif,Abdulla Watad,Nicola Luigi Bragazzi,Micheal Lichtbroun,Howard Amital,Yehuda Shoenfeld,Yehuda Shoenfeld +6 more
TL;DR: Clinical evidence regarding the safety, barriers to engagement, and impact of physical activity on autoimmune diseases is reviewed, showing physical activity has been shown to be safe in most of autoimmune diseases.
Journal ArticleDOI
Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model.
TL;DR: The evidence presented in this review supports HS as an auto-inflammatory skin disorder associated with alterations in the innate immune system and further research is warranted to ultimately improve the management and treatment of patients with HS and related syndromic conditions.
References
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Journal ArticleDOI
VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis
Franco Scaldaferri,Stefania Vetrano,Miquel Sans,Vincenzo Arena,Giuseppe Straface,Egidio Stigliano,Alessandro Repici,Andreas Sturm,Alberto Malesci,Julián Panés,Seppo Ylä-Herttuala,Claudio Fiocchi,Silvio Danese +12 more
TL;DR: VEGF-A appears to be a novel mediator of IBD by promoting intestinal angiogenesis and inflammation, and agents that block VEGf-A signaling might reduce intestinal inflammation in patients with IBD.
Journal ArticleDOI
Increased Expression of IP-10, IL-8, MCP-1, and MCP-3 in Ulcerative Colitis
Mariagrazia Uguccioni,Paolo Gionchetti,Davide F. Robbiani,Fernando Rizzello,Sabrina Peruzzo,Massimo Campieri,Marco Baggiolini +6 more
TL;DR: IP-10 was also markedly expressed in the mucosa of control biopsies and therefore could have a role in activated T lymphocytes' recruitment into the healthy mucosa and therefore should be considered for investigation in ulcerative colitis patients.
Journal ArticleDOI
Fibrogenesis in Crohn's disease.
John P. Burke,Jurgen Mulsow,Conor O'Keane,Neil G. Docherty,R. William G. Watson,P. Ronan O’Connell +5 more
TL;DR: Greater understanding of the biology of fibrostenosis is likely to yield significant advances in the ability to care for patients with stricturing CD, and potential dividends include identification of novel therapeutic targets and biomarkers useful for prognostication and therapeutic monitoring.
Journal ArticleDOI
Absorption of 151chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease
TL;DR: Intestinal permeability was assessed in patients with inflammatory bowel disease by measuring the urine excretion of 151 chromium-labeled ethylenediaminetetraacetate over periods up to 24 h after oral administration to appear to be a sensitive, noninvasive test for assessing small intestinal integrity.
Journal ArticleDOI
Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis
Richard Hansen,Richard K Russell,Caroline Reiff,Petra Louis,Freda M McIntosh,Susan H. Berry,Indrani Mukhopadhya,W. Michael Bisset,A. R. Barclay,J. Bishop,Diana M. Flynn,Paraic McGrogan,S Loganathan,Gamal Mahdi,Harry J. Flint,Emad M. El-Omar,Georgina L. Hold +16 more
TL;DR: The results challenge the current model of a protective role for F. prausnitzii in CD, suggesting a more dynamic role for this organism than previously described.