Journal ArticleDOI
Identification of a cannabimimetic indole as a designer drug in a herbal product
TLDR
A cannabimimetic indole has been identified as a new adulterant in a herbal product being sold illegally in Japan for its expected narcotic effect as mentioned in this paper, which was reported as a potent cannabinoid receptor agonist possessing a pharmacological cannabolimetic activity.Abstract:
A cannabimimetic indole has been identified as a new adulterant in a herbal product being sold illegally in Japan for its expected narcotic effect. Liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry analyses indicated that the product contained two major compounds. One was identified as a cannabinoid analog (1RS,3SR)-3-[4-(1,1-dimethyloctyl)-2-hydroxyphenyl]cyclohexan-1-ol (1) by direct comparison with the authentic compound, which we reported previously. The other compound (2) showed a molecular weight of 341 daltons, and accurate mass spectral measurements showed its elemental composition to be C24H23NO. Both mass and nuclear magnetic resonance spectrometric data revealed that 2 was 1-pentyl-3-(1-naphthoyl)indole [or naphthalen-1-yl-(1-pentylindol-3-yl)methanone] being identical to JWH-018, which was synthesized by Wiley and coworkers in 1998. This compound was reported as a potent cannabinoid receptor agonist possessing a pharmacological cannabimimetic activity.read more
Citations
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Beyond THC: The New Generation of Cannabinoid Designer Drugs
TL;DR: An escalating number of compounds with cannabinoid receptor activity are currently being found as ingredients of Spice, of which almost nothing is known in terms of pharmacology, toxicology, and safety.
Journal ArticleDOI
Spice drugs as a new trend: Mode of action, identification and legislation
TL;DR: Although it remains unclear where and how the actual production of the herbal mixtures takes place, it is evident that producers are purposely risk the health of consumers to skim high profits.
Journal ArticleDOI
Chemical analysis of synthetic cannabinoids as designer drugs in herbal products.
TL;DR: Several synthetic cannabinoids were found in 44 of 46 different kinds of herbal products that are currently distributed on the illegal drug market in Japan due to their expected narcotic effects.
Journal ArticleDOI
Detection of JWH-018 metabolites in smoking mixture post-administration urine.
TL;DR: Using gas and liquid chromatography combined with tandem mass spectrometry two main monohydroxylated metabolites were identified in the forensic urine samples of JWH-018 and it is supposed that one is formed by hydroxylation of the indole ring whilst the other by Hydroxylations of the N-alkyl chain.
Journal ArticleDOI
Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.
Samuel D. Banister,Mitchell Longworth,Richard C. Kevin,Shivani Sachdev,Marina Santiago,Jordyn Stuart,James B. C. Mack,Michelle Glass,Iain S. McGregor,Mark Connor,Michael Kassiou +10 more
TL;DR: In vitro and in vivo data indicate that these SCs act as highly efficacious CB receptor agonists with greater potency than Δ(9)-THC and earlier generations of SCs.
References
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Journal Article
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