Journal ArticleDOI
IgG4-related disease
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TLDR
Identification of specific antigens and T-cell clones that drive the disease will be the first steps to elucidate the pathogenesis of IgG4-related disease.Citations
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Mechanisms underlying B cell immune dysregulation and autoantibody production in MuSK myasthenia gravis.
Panos Stathopoulos,Aditya Kumar,Jason A. Vander Heiden,Elba Pascual-Goñi,Richard Nowak,Kevin C. O’Connor +5 more
TL;DR: In this article, the authors found that B cell tolerance defects contribute to the abnormal development of the naive repertoire, which indicates that dysregulation occurs before the production of autoantibodies.
Journal ArticleDOI
Bullous pemphigoid suggestive of complement-independent blister formation with anti-BP180 IgG4 autoantibodies
Teruki Dainichi,Wataru Nishie,Y. Yamagami,H. Sonobe,Hideyuki Ujiie,Yo Kaku,Kenji Kabashima,Kenji Kabashima,Kenji Kabashima +8 more
TL;DR: Two cases of pemphigoid, without complement activation at the BMZ, are reported, which may partly explain the clinical diversity in pemPHigoid diseases.
Journal ArticleDOI
Sarcoidosis and autoimmune diseases: differences, similarities and overlaps.
TL;DR: A systematic diagnostic work-up is necessary to detect overlapping disease features in patients with sarcoidosis, and immune-modulating therapies need to be taken into account as these can induce paradoxical reactions.
Journal ArticleDOI
Imaging Manifestations of Hematologic Diseases with Renal and Perinephric Involvement.
Andrei S. Purysko,Antonio C. Westphalen,Erick M. Remer,Christopher P. Coppa,Hilton Leão Filho,Brian R. Herts +5 more
TL;DR: Familiarity with the imaging patterns of renal and perinephric involvement and key clinical and histopathologic features may help to narrow the differential diagnosis and determine the next step of care.
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Soluble Interleukin-2 Receptor: A Potential Marker for Monitoring Disease Activity in IgG4-Related Disease.
TL;DR: Serum sIL-2R is elevated in IgG4-RD reflecting the inflammatory process with enhanced T-cell activation, and might serve as a potential marker of response to treatment in IgT-cells-related disease.
References
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Journal ArticleDOI
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
Journal ArticleDOI
Differentiation of Effector CD4 T Cell Populations
TL;DR: This review summarizes the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
Journal ArticleDOI
Alternative Activation of Macrophages: An Immunologic Functional Perspective
TL;DR: The cellular sources of these cytokines, receptor signaling pathways, and induced markers and gene signatures are reviewed and the concept of macrophage activation in the context of the immune response is revisit.
Journal ArticleDOI
The regulation of IL-10 production by immune cells
Margarida Saraiva,Anne O'Garra +1 more
TL;DR: Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
Journal ArticleDOI
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hideaki Hamano,Shigeyuki Kawa,Akira Horiuchi,Hiroshi Unno,Naoyuki Furuya,Taiji Akamatsu,Mana Fukushima,Toshio Nikaido,Kohzo Nakayama,Nobuteru Usuda,Kendo Kiyosawa +10 more
TL;DR: Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.
Related Papers (5)
Consensus statement on the pathology of IgG4-related disease
Vikram Deshpande,Yoh Zen,John Kc Chan,Eunhee E Yi,Yasuharu Sato,Tadashi Yoshino,Günter Klöppel,J. Godfrey Heathcote,Arezou Khosroshahi,Judith A. Ferry,Rob C. Aalberse,Daniel Bloch,William R. Brugge,Adrian C Bateman,Mollie N. Carruthers,Suresh T. Chari,Wah Cheuk,Lynn D. Cornell,Carlos Fernandez-del Castillo,David G. Forcione,Daniel L. Hamilos,Terumi Kamisawa,Satomi Kasashima,Shigeyuki Kawa,Mitsuhiro Kawano,Gregory Y. Lauwers,Yasufumi Masaki,Yasuni Nakanuma,Kenji Notohara,Kazuichi Okazaki,Ji Kon Ryu,Takako Saeki,Dushyant V. Sahani,Thomas C. Smyrk,James Robert Stone,Masayuki Takahira,George Webster,Motohisa Yamamoto,Giuseppe Zamboni,Hisanori Umehara,John H. Stone +40 more
Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011
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International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease
Arezou Khosroshahi,Zachary S. Wallace,J. L. Crowe,Takashi Akamizu,Atsushi Azumi,M. N. Carruthers,Suresh T. Chari,Emanuel Della-Torre,Luca Frulloni,Hiroshi Goto,Phil A. Hart,Terumi Kamisawa,Shigeyuki Kawa,Mitsuhiro Kawano,Myung-Hwan Kim,Yuzo Kodama,Kensuke Kubota,Markus M. Lerch,Matthias Löhr,Yasufumi Masaki,Shoko Matsui,Tsuneyo Mimori,Seiji Nakamura,Takahiro Nakazawa,Hirotaka Ohara,Kazuichi Okazaki,Jay H. Ryu,Takako Saeki,Nicolas Schleinitz,Akira Shimatsu,Toru Shimosegawa,Hiroki Takahashi,Masayuki Takahira,Atsushi Tanaka,Mark Topazian,Hisanori Umehara,George J. Webster,Thomas E. Witzig,Motohisa Yamamoto,W. Zhang,Tsutomu Chiba,John H. Stone +41 more