Journal ArticleDOI
IgG4-related disease
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TLDR
Identification of specific antigens and T-cell clones that drive the disease will be the first steps to elucidate the pathogenesis of IgG4-related disease.Citations
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Efficacy of Cyclophosphamide treatment for immunoglobulin G4-related disease with addition of glucocorticoids
Fei Yunyun,Chen Yu,Zhang Panpan,Chen Hua,Wu Di,Zhao Lidan,Peng Linyi,Wang Li,Wu Qingjun,Zhang Xuan,Zhao Yan,Zeng Xiao-feng,Zhang Fengchun,Zhang Wen +13 more
TL;DR: Evaluated the efficacy and safety of glucocorticoid monotherapy vs combination therapy of cyclophosphamide (CYC) for IgG4 related disease (IgG4-RD) and found IgG 4 levels of relapse cases were significantly higher than non-relapsing patients at baseline.
Journal ArticleDOI
On the role of IgG4 in inflammatory conditions: lessons for IgG4-related disease
TL;DR: IgG4 alone can implement pathogenic effects and structural damage, but may also function as a protective antibody dampening the more harmful effects of IgG1 when directed against the same epitopes.
Journal ArticleDOI
Long-Lived Plasma Cells in Mice and Men
Siggeir F. Brynjolfsson,Linn Persson Berg,Teresa Olsen Ekerhult,Inga Rimkute,Mary Jo Wick,Inga-Lill Mårtensson,Ola Grimsholm,Ola Grimsholm +7 more
TL;DR: Current knowledge of LLPCs is discussed, comparing mice and humans, and the mechanisms behind high persisting antibody titers in the absence of the causative agent are still unclear.
Journal ArticleDOI
Erdheim-Chester disease
TL;DR: Targeted therapies have an overall, robust and reproducible efficacy in ECD, with no acquired resistance to date, but their use may be best reserved for the most severe manifestations of the disease, as they may be associated with serious side-effects and as yet unknown long-term consequences.
Journal ArticleDOI
T Cell Polarization toward TH2/TFH2 and TH17/TFH17 in Patients with IgG4-Related Disease.
Aurélie Grados,Mikael Ebbo,Christelle Piperoglou,Matthieu Groh,Alexis Régent,Maxime Samson,Benjamin Terrier,Anderson Loundou,Nathalie Morel,Sylvain Audia,François Maurier,Julie Graveleau,Mohamed Hamidou,Amandine Forestier,S. Palat,Emmanuelle Bernit,Bernard Bonotte,Catherine Farnarier,Jean-Robert Harlé,Nathalie Costedoat-Chalumeau,Frédéric Vély,Nicolas Schleinitz +21 more
TL;DR: In this article, the authors examined and characterized subsets of circulating lymphocytes in untreated patients with active IgG4-related disease, showing an increase of circulating T regulatory, TH2, TH17, and CD4+CXCR5+PD1+ TFH cell subsets.
References
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Journal ArticleDOI
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
Journal ArticleDOI
Differentiation of Effector CD4 T Cell Populations
TL;DR: This review summarizes the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
Journal ArticleDOI
Alternative Activation of Macrophages: An Immunologic Functional Perspective
TL;DR: The cellular sources of these cytokines, receptor signaling pathways, and induced markers and gene signatures are reviewed and the concept of macrophage activation in the context of the immune response is revisit.
Journal ArticleDOI
The regulation of IL-10 production by immune cells
Margarida Saraiva,Anne O'Garra +1 more
TL;DR: Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
Journal ArticleDOI
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hideaki Hamano,Shigeyuki Kawa,Akira Horiuchi,Hiroshi Unno,Naoyuki Furuya,Taiji Akamatsu,Mana Fukushima,Toshio Nikaido,Kohzo Nakayama,Nobuteru Usuda,Kendo Kiyosawa +10 more
TL;DR: Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.
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