Journal ArticleDOI
Impact of albumin on drug delivery--new applications on the horizon.
TLDR
An overview of the expanding field of preclinical and clinical drug applications and developments that use albumin as a protein carrier to improve the pharmacokinetic profile of the drug or to target the drug to the pathogenic site addressing diseases with unmet medical needs is given.About:
This article is published in Journal of Controlled Release.The article was published on 2012-01-10. It has received 716 citations till now. The article focuses on the topics: Serum albumin & Human serum albumin.read more
Citations
More filters
Journal ArticleDOI
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.
TL;DR: This review offers a detailed description of different cytotoxic drug carriers, such as liposomes, carbon nanotubes, dendrimers, polymeric micelles,polymeric conjugates and polymeric nanoparticles, in passive and active targeted cancer therapy, by enhancing the permeability and retention or by the functionalization of the surface of the carriers.
Journal ArticleDOI
Protein-based nanocarriers as promising drug and gene delivery systems
TL;DR: The current review highlights the main advances achieved in utilizing protein nanocarriers as natural vehicles for drug and gene delivery tasks with respect to types, advantages, limitations, formulation aspects as well as the major outcomes of the in vitro and in vivo investigations.
Journal ArticleDOI
Smart Human Serum Albumin-Indocyanine Green Nanoparticles Generated by Programmed Assembly for Dual-Modal Imaging-Guided Cancer Synergistic Phototherapy
Zonghai Sheng,Dehong Hu,Mingbin Zheng,Pengfei Zhao,Huilong Liu,Duyang Gao,Ping Gong,Guanhui Gao,Pengfei Zhang,Yifan Ma,Lintao Cai +10 more
TL;DR: The results suggest that HSA-ICG NPs generated by programmed assembly as smart theranostic nanoplatforms are highly potential for imaging-guided cancer phototherapy with PDT/PTT synergistic effects.
Journal ArticleDOI
Biopolymer-based nanoparticles for drug/gene delivery and tissue engineering.
Sachiko Nitta,Keiji Numata +1 more
TL;DR: In this article, a review of fabrication of biocompatible nanoparticles consisting of biopolymers such as protein (silk, collagen, gelatin, β-casein, zein and albumin), protein-mimicked polypeptides and polysaccharides (chitosan, alginate, pullulan, starch and heparin).
References
More filters
Journal ArticleDOI
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
Dennis J. Slamon,Brian Leyland-Jones,Steven Shak,Hank Fuchs,Virginia E. Paton,Alex Bajamonde,Thomas Fleming,Wolfgang Eiermann,Janet M. Wolter,Mark D. Pegram,José Baselga,Larry Norton +11 more
TL;DR: The addition of trastuzumab to chemotherapy was associated with a longer time to disease progression, a higher rate of objective response, a longer duration of response, and a lower rate of death at 1 year.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Walter Stummer,Uwe Pichlmeier,Thomas Meinel,Otmar D. Wiestler,Friedhelm E. Zanella,Hans-Jürgen Reulen +5 more
TL;DR: Tumour fluorescence derived from 5-aminolevulinic acid enables more complete resections of contrast-enhancing tumour, leading to improved progression-free survival in patients with malignant glioma.
Journal ArticleDOI
Glutamate, nitric oxide and cell-cell signalling in the nervous system
TL;DR: In this paper, it was shown that NO is produced enzymatically in postsynaptic structures in response to activation of excitatory amino acid receptors and diffuses out to act on neighbouring cellular elements, probably presynaptic nerve endings and astrocyte processes.