Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS-EEG and working memory performance
Sung Wook Chung,Nigel C. Rogasch,Kate E. Hoy,Caley Sullivan,Robin F.H. Cash,Paul B. Fitzgerald +5 more
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TLDR
Neurophysiological changes associated with working memory following iTBS suggest functional relevance, but the effects of different intensities on behavioural performance remain elusive in the present healthy sample, and should be carefully considered for clinical populations.Abstract:
Intermittent theta burst stimulation (iTBS) is a noninvasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex. Sixteen healthy participants received iTBS over prefrontal cortex at either 50, 75 or 100% resting motor threshold in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials and oscillations. The n-back task was used to assess changes in working memory performance. The data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS yielded the largest neurophysiological changes. Improvement in reaction time in the 3-back task was supported by the change in alpha power, however, comparison between conditions revealed no significant differences. The assumption that higher intensity results in greater neuromodulatory effects may be false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.read more
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Journal ArticleDOI
Clinical utility and prospective of TMS–EEG
Sara Tremblay,Sara Tremblay,Nigel C. Rogasch,Isabella Premoli,Daniel M. Blumberger,Silvia Casarotto,Robert Chen,Vincenzo Di Lazzaro,Faranak Farzan,Fabio Ferrarelli,Paul B. Fitzgerald,Paul B. Fitzgerald,Jeanette Hui,Risto J. Ilmoniemi,Vasilios K. Kimiskidis,Dimitris Kugiumtzis,Pantelis Lioumis,Alvaro Pascual-Leone,Maria Concetta Pellicciari,Tarek K. Rajji,Gregor Thut,Reza Zomorrodi,Ulf Ziemann,Zafiris J. Daskalakis +23 more
TL;DR: A comprehensive review of studies that have used TMS-EEG in clinical populations and to discuss potential clinical applications is presented, including recommendations for how to address some of the salient challenges faced in clinical TMS -EEG research.
Posted ContentDOI
Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression (SAINT-TRD)
E. Cole,Katy H. Stimpson,M. Gulser,Kirsten Cherian,Claudia Tischler,Romina Nejad,Brandon S. Bentzley,Heather Pankow,Elizabeth Choi,Haley Aaron,Flint M. Espil,Jaspreet Pannu,Xiaoqian Xiao,Dalton Duvio,Hugh B. Solvason,Jessica Hawkins,Jennifer Keller,Alan F. Schatzberg,Keith Sudheimer,Nolan R. Williams +19 more
TL;DR: The authors' accelerated, high-dose, iTBS protocol with fcMRI-guided targeting (SAINT) was well tolerated and safe, especially for this treatment-resistant population, and effectiveness was strikingly high.
Journal ArticleDOI
Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects.
TL;DR: These results provide important initial insight into the behavioural and biological effects of stimulation over key cortical regions linked to WM and attest to the sensitivity of TMS-EEG and EEG in detecting subtle neurophysiological changes induced by HD-tDCS.
Journal ArticleDOI
The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS-EEG study.
Sung Wook Chung,Caley Sullivan,Nigel C. Rogasch,Kate E. Hoy,Neil W. Bailey,Robin F.H. Cash,Paul B. Fitzgerald +6 more
TL;DR: Tailored stimulation parameters appear more efficacious than standard paradigms in neurophysiological and mood changes in humans and benefits may extend to clinical applications.
Journal ArticleDOI
Critical role of glutamatergic and GABAergic neurotransmission in the central mechanisms of theta-burst stimulation.
Cheng Ta Li,Ying-Zu Huang,Ya Mei Bai,Ya Mei Bai,Shih-Jen Tsai,Shih-Jen Tsai,Tung Ping Su,Chih-Ming Cheng,Chih-Ming Cheng +8 more
TL;DR: The latest findings on TBS are reviewed from animal and human experiments on glutamatergic and GABAergic neurotransmissions in response to TBS, and an updated theoretical model integrating glutamaterspinephrine and glutamate neurotransmissions is proposed.
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