Open AccessJournal Article
Impact of the discovery of human zinc deficiency
TLDR
Zinc supplementation in the elderly results in decreased incidence of infections, decreased oxidative stress and decreased generation of inflammatory cytokines.Abstract:
The essentiality of zinc in humans was established in 1963. During the past 50y, tremendous advances in both clinical and basic sciences of zinc metabolism in humans have been observed. Growth retardation; cell-mediated immune dysfunction, and cognitive impairment are major clinical effects in human. At present we know of >300 enzymes and >1000 transcription factors that require zinc for their activities. Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling events. Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson's disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration. Zinc not only modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent. Zinc supplementation in the elderly results in decreased incidence of infections, decreased oxidative stress and decreased generation of inflammatory cytokines.read more
Citations
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Zinc signals and immune function
Hajo Haase,Lothar Rink +1 more
TL;DR: Main mechanisms by which zinc ions exert essential functions in the immune system are focused on, including tightly protein bound zinc ions serving catalytic or structural functions in a multitude of different proteins, in particular enzymes and transcription factors.
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Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms.
TL;DR: This study presents selected issues regarding the current knowledge of anti-cancer mechanisms involving this element, including the influence of zinc on the immune system, transcription factors, cell differentiation and proliferation, DNA and RNA synthesis and repair, enzyme activation or inhibition, and the regulation of cellular signaling.
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Rice NICOTIANAMINE SYNTHASE 2 expression improves dietary iron and zinc levels in wheat.
TL;DR: Wheat lines that meet or exceed recommended dietary target levels for iron and zinc in the grains are developed that represent useful germplasm for breeding new wheat varieties that can reduce micronutrient deficiencies in affected populations.
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Parasite Sensing of Host Nutrients and Environmental Cues
TL;DR: An overview of the nutritional needs of different parasites throughout their diverse life stages is provided and recent insights into strategies that both hosts and parasites have developed to meet these nutritional requirements needed for defense, survival, and replication are highlighted.
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Alterations in the Gut ( Gallus gallus) Microbiota Following the Consumption of Zinc Biofortified Wheat ( Triticum aestivum)-Based Diet.
Spenser Reed,Spenser Reed,Marija Knez,Atara Uzan,James C. R. Stangoulis,Raymond P. Glahn,Omry Koren,Elad Tako +7 more
TL;DR: The data demonstrate that the gut microbiome associated with Zn biofortified wheat ingestion is unique and may influence host Zn status, and the Ruminococcus genus appeared to be a key player in delineating the Zn replete microbiota from the control group, as it strongly predicts host ZN adequacy.
References
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Journal ArticleDOI
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
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TL;DR: People older than 55 years should have dilated eye examinations to determine their risk of developing advanced AMD and those with extensive intermediate size drusen, at least 1 large druse, noncentral geographic atrophy in 1 or both eyes, or advanced AMD or vision loss due to AMD in 1 eye should consider taking a supplement of antioxidants plus zinc.
Journal ArticleDOI
Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia.
TL;DR: Prolonged follow-up of patients receiving a well balanced diet indicates that the endocrine abnormalities of growth and sexual development are reversible.
Journal Article
Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypognadism.
Journal ArticleDOI
Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease
TL;DR: Zinc has been very successfully used as a therapeutic modality for the management of acute diarrhea in children, Wilson’s disease, the common cold and for the prevention of blindness in patients with age-related dry type of macular degeneration and is very effective in decreasing the incidence of infection in the elderly.
Journal ArticleDOI
Zinc: role in immunity, oxidative stress and chronic inflammation
TL;DR: Zinc supplementation was effective in decreasing oxidative stress and generation of inflammatory cytokines such as TNF-α and IL-1β in elderly individuals and patients with SCD and decreasing incidences of respiratory tract infections in children.