Journal ArticleDOI
In situ antibody detection and charge discrimination using aqueous stable pentacene transistor biosensors.
Reads0
Chats0
TLDR
This demonstration of fast, label-free, real-time detection of nanoscale biomolecules in aqueous buffer solutions using the organic transistor sensing platform will have a significant impact on high-performance microarrays in addition to discriminating the presence of ionizable groups.Abstract:
Pentacene-based organic thin-film transistors were used to create highly sensitive, real-time electronic sensors for selective antibody detection. Bovine serum albumin was covalently attached to a modified pentacene surface to selectively detect the label free monoclonal antiBSA. These sensors displayed a high affinity constant (K(A)) of (1.1 ± 3) × 10(7) M(-1) at pH 7, which is 1 order of magnitude higher than those obtained with a highly sensitive surface plasmon resonance spectroscopy detection system. Furthermore, a high degree of discrimination in the hybrid antiBSA charges was achieved at different pH values. This demonstration of fast, label-free, real-time detection of nanoscale biomolecules in aqueous buffer solutions using the organic transistor sensing platform will have a significant impact on high-performance microarrays in addition to discriminating the presence of ionizable groups.read more
Citations
More filters
Journal ArticleDOI
25th Anniversary Article: The Evolution of Electronic Skin (E-Skin): A Brief History, Design Considerations, and Recent Progress
TL;DR: Electronic networks comprised of flexible, stretchable, and robust devices that are compatible with large-area implementation and integrated with multiple functionalities is a testament to the progress in developing an electronic skin akin to human skin.
Journal ArticleDOI
Organic field-effect transistor sensors: a tutorial review
TL;DR: The functioning principles of electronic sensors based on organic semiconductor field-effect transistors (OFETs) are presented and the perspective use of such devices in point-of-care is introduced after some basics on analytical biosensing systems are provided.
Journal ArticleDOI
Chemical and engineering approaches to enable organic field-effect transistors for electronic skin applications.
Anatoliy N. Sokolov,Benjamin C. K. Tee,Christopher J. Bettinger,Jeffrey B.-H. Tok,Zhenan Bao +4 more
TL;DR: Progress to date suggests that OFETs may be integrated within a single substrate to function as an electronic mimic of human skin, which could enable a large range of sensing-related applications from novel prosthetics to robotic surgery.
Journal ArticleDOI
Chemical and Biomolecule Sensing with Organic Field-Effect Transistors
TL;DR: This review highlights recent progress in organic field-effect transistor (OFET) chemical sensors, emphasizing advances from the past 5 years and including aspects of OSC morphology and the role of adjacent dielectrics.
Journal ArticleDOI
Magneto-controlled graphene immunosensing platform for simultaneous multiplexed electrochemical immunoassay using distinguishable signal tags.
TL;DR: A novel flow-through multiplexed immunoassay protocol for simultaneous electrochemical determination of carcinoembryonic (CEA) and alpha-fetoprotein (AFP) in biological fluids was designed using biofunctionalized magnetic graphene nanosheets (MGO) as immunosensing probes and multifunctional nanogold hollow microspheres (GHS) as distinguishable signal tags.
References
More filters
Journal ArticleDOI
The adsorption of gases on plane surfaces of glass, mica and platinum.
TL;DR: In this article, the absorption index at the wave length of the band maximum was found to be proportional to the total concentration of metal at shorter wave lengths, however, deviations were observed, the absorption increasing more rapidly with concentration than Beers' law would demand.
Journal ArticleDOI
High-mobility polymer gate dielectric pentacene thin film transistors
TL;DR: In this article, a spin-coated polymer gate dielectric layer was used to obtain a polyvinylphenol-based copolymer-based transistor with a carrier mobility as large as 3 cm2/V's and sub-threshold swing as low as 0.5 V/decade.
Journal ArticleDOI
Quantitative determination of surface concentration of protein with surface plasmon resonance using radiolabeled proteins
TL;DR: In this article, a methodology to correlate the absolute surface concentration of protein to the surface plasmon resonance (SPR) response is described, and the thickness and the optical constants for each layer on the sensor chip used were determined with different optical techniques.
Journal ArticleDOI
Patterning organic single-crystal transistor arrays.
Alejandro L. Briseno,Alejandro L. Briseno,Stefan C. B. Mannsfeld,Mang M. Ling,Shuhong Liu,Ricky J. Tseng,Colin Reese,Mark E. Roberts,Yang Yang,Fred Wudl,Zhenan Bao +10 more
TL;DR: The results suggest that the fabrication approach constitutes a promising step that might ultimately allow to utilize high-performance organic single-crystal field-effect transistors for large-area electronics applications.
Journal ArticleDOI
Interfaces and thin films as seen by bound electromagnetic waves
TL;DR: An emphasis is put on the combination set-up of surface plasmon optics with electrochemical techniques, allowing for the on-line characterization of various surface functionalization strategies, e.g. for (bio-) sensor purposes.