Journal ArticleDOI
In Vitro Gene Delivery with Large Porous Silicon Nanoparticles Fabricated Using Cost‐Effective, Metal‐Assisted Chemical Etching
Nancy Wareing,Kyle Szymanski,Giridhar R. Akkaraju,Armando Loni,Leigh T. Canham,Roberto Gonzalez-Rodriguez,Jeffery L. Coffer +6 more
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TLDR
The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal-assisted stain-etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney cells is demonstrated, suggesting the possibility of using such material for targeted transfection and drug delivery.Abstract:
The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal-assisted stain-etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney (HEK293) cells is demonstrated, suggesting the possibility of using such material for targeted transfection and drug delivery.read more
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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy.
Tuying Yong,Xiaoqiong Zhang,Nana Bie,Hongbo Zhang,Xuting Zhang,Fuying Li,Abdul Hakeem,Jun Hu,Lu Gan,Hélder A. Santos,Xiangliang Yang +10 more
TL;DR: A biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy and show their therapeutic potential in targeting tumours and cancer stem cells in multiple mouse models are generated.
Journal ArticleDOI
Tailoring Porous Silicon for Biomedical Applications : From Drug Delivery to Cancer Immunotherapy
TL;DR: Very promising research results encourage further exploration of porous silicon for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications.
Journal ArticleDOI
Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine.
Wei Li,Yunzhan Li,Zehua Liu,Nattha Kerdsakundee,Ming Zhang,Feng Zhang,Xueyan Liu,Tomás Bauleth-Ramos,Wenhua Lian,Ermei Mäkilä,Marianna Kemell,Yaping Ding,Bruno Sarmento,Ruedeekorn Wiwattanapatapee,Jarno Salonen,Hongbo Zhang,Jouni Hirvonen,Dongfei Liu,Xianming Deng,Hélder A. Santos +19 more
TL;DR: Haluronic acid functionalized porous silicon nanoparticle is used to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured vehicle with programmed properties to fully and sequentially overcome the multiple obstacles for efficiently delivering drugs locally to inflamed sites of intestine.
Journal ArticleDOI
Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties.
Jianqiao Liu,Jia Liu,Shokouh Attarilar,Chong Wang,Maryam Tamaddon,Chengliang Yang,Kegong Xie,Jinguang Yao,Liqiang Wang,Chaozong Liu,Yujin Tang +10 more
TL;DR: The research progress on the antibacterial properties of various surface nano-modification of titanium implant materials and the related procedures are introduced, and the new trends will be discussed in order to improve the related materials and methods.
Journal ArticleDOI
A MACEing Silicon: Towards single-step etching of defined porous nanostructures for biomedicine
Hashim Alhmoud,Hashim Alhmoud,D. Brodoceanu,D. Brodoceanu,Roey Elnathan,Roey Elnathan,Roey Elnathan,Tobias Kraus,Tobias Kraus,Nicolas H. Voelcker +9 more
TL;DR: A comprehensive overview of the metal-assisted chemical etching (MACE) reaction mechanism that yields biomedically relevant silicon nanostructures can be found in this article, where they discuss their biomedical applications in biosensors, cell capture and transfection arrays, and drug delivery vectors.
References
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Progress in developing cationic vectors for non-viral systemic gene therapy against cancer.
TL;DR: The aim of this review is to describe the "perfect vector" for systemic gene therapy against cancer based on the advantages and disadvantages of existing vectors and on the hurdles encountered with these carriers.
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Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain.
Dhruba J. Bharali,Ilona Klejbor,Ewa K. Stachowiak,Purnendu Dutta,Indrajit Roy,Navjot Kaur,Earl J. Bergey,Paras N. Prasad,Michal K. Stachowiak +8 more
TL;DR: The results of this nanomedicine approach using ORMOSIL nanoparticles as a nonviral gene delivery platform have a promising future direction for effective therapeutic manipulation of the neural stem/progenitor cells as well as in vivo targeted brain therapy.
Journal ArticleDOI
Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery
Indrajit Roy,Tymish Y. Ohulchanskyy,Dhruba J. Bharali,Haridas E. Pudavar,Ruth A. Mistretta,Navjot Kaur,Paras N. Prasad +6 more
TL;DR: The work shows that the nanomedicine approach, with nanoparticles acting as a drug-delivery platform combining multiple optical and other types of probes, provides a promising direction for targeted therapy with enhanced efficacy as well as for real-time monitoring of drug action.
Journal ArticleDOI
Gene therapy progress and prospects: non-viral gene therapy by systemic delivery
Shyh-Dar Li,Leaf Huang +1 more
TL;DR: This review focuses on the progress made over the last 2 years in developing gene carriers that can be targeted to the disease site and some future prospects for gene delivery.