Journal ArticleDOI
Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer
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In this paper, it was shown that 3T3-L1 adipocytes in obese mice exhibit increased reactive oxygen species (ROS) with lipid accumulation; the addition of free fatty acids elevates ROS generation further.About:
This article is published in Obesity Research & Clinical Practice.The article was published on 2013-09-01. It has received 493 citations till now. The article focuses on the topics: Type 2 diabetes & Metabolic syndrome.read more
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On the central role of mitochondria dysfunction and oxidative stress in Alzheimer's disease.
TL;DR: Mitochondria dysfunction and oxidative stress play a critical role in AD etiopathogenesis and pathophysiology, and treatment and prevention strategies must be geared towards improving mitochondrial function and attenuating oxidative stress.
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Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders.
Andrea Rodrigues Vasconcelos,Nilton Barreto dos Santos,Cristoforo Scavone,Carolina Demarchi Munhoz +3 more
TL;DR: Current knowledge of the role of Nrf2 signaling in neurological diseases, namely Alzheimer's disease, Parkinson’s disease, multiple sclerosis and cerebral ischemia, as well as the potential of energy intake regulation in the management of NRF2 signaling are reviewed.
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Oxidative stress, type 2 diabetes and vitamin D: past, present and future.
TL;DR: The latest information on the possible links of oxidative stress with diabetes development, control and complications as well as the newest results of antioxidant supplementation trials is reviewed and the possible role of vitamin D, as a newly recognized antioxidant in diabetes is discussed.
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Type 2 Diabetes and Breast Cancer: The Interplay between Impaired Glucose Metabolism and Oxidant Stress.
Patrizia Ferroni,Silvia Riondino,Oreste Claudio Buonomo,Raffaele Palmirotta,Fiorella Guadagni,Mario Roselli +5 more
TL;DR: The advances in understanding of the mechanisms linking metabolic disorders and breast cancer are discussed, with a major role played by the dysregulated glucose metabolism, which concurs with a chronic proinflammatory condition and an associated oxidative stress to promote tumour initiation and progression.
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Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics.
Kathryn T. Weber,Timothy Jacobsen,Robert Maidhof,Justin Virojanapa,Chris Overby,Ona Bloom,Ona Bloom,Shaheda Quraishi,Mitchell Levine,Nadeen O. Chahine,Nadeen O. Chahine +10 more
TL;DR: Findings on the biochemical changes in disc diseases, including cytokines, chemokines, and proteases, and recent developments in repair strategies, including cell-based repair, biomaterials, and tissue engineering are reviewed.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.