Journal ArticleDOI
Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer
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In this paper, it was shown that 3T3-L1 adipocytes in obese mice exhibit increased reactive oxygen species (ROS) with lipid accumulation; the addition of free fatty acids elevates ROS generation further.About:
This article is published in Obesity Research & Clinical Practice.The article was published on 2013-09-01. It has received 493 citations till now. The article focuses on the topics: Type 2 diabetes & Metabolic syndrome.read more
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Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis.
TL;DR: By modulating PDMPs or PAI-1, teneligliptin shows an antiatherothrombotic effect that may be beneficial in the primary prevention of CVD in patients with T2DM on HD.
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Lycopene-supplemented diet ameliorates metabolic syndrome induced by fructose in rats
TL;DR: Lycopene treatment significantly attenuated the development of hypertension and endothelial dysfunction and prevented cardiac hypertrophy, but had no effect in rats fed with standard diet, suggesting that lycopene significantly attenuates pathophysiological condition of metabolic syndrome caused by fructose consumption.
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Mitochondrial inefficiency in infants born to overweight African-American mothers.
Manjusha Abraham,Christina A. Collins,Scott Flewelling,Maraya Camazine,Alison G. Cahill,W. Todd Cade,Jennifer G. Duncan +6 more
TL;DR: This study demonstrates altered mitochondrial function and oxidative stress in skin fibroblasts of infants born to overweight mothers and future studies are needed to determine the long-term impact of this finding on the metabolic health of these children.
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The Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological Correction
E S Prokudina,Leonid N. Maslov,Vladimir V. Ivanov,I D Bespalova,D. S. Pismennyi,Nikita S. Voronkov +5 more
TL;DR: The positive results in the treatment of metabolic syndrome by losartan were obtained and Antioxidants and flavonoids exhibit a positive impact on the course of the experimental metabolic syndrome.
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An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice
Ying Fu,Shana Silverstein,Justine N. McCutcheon,Marcin Dyba,Raghu G. Nath,Monika Aggarwal,Heidi Coia,Angela Bai,Jishen Pan,Jiji Jiang,Bhaskar Kallakury,Hongkun Wang,Yu-Wen Zhang,Giuseppe Giaccone,Aiwu Ruth He,Fung-Lung Chung +15 more
TL;DR: Results support γ‐OHPdG as a mechanism‐based, biologically relevant biomarker for predicting the risk of HCC and its recurrence.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.