Journal ArticleDOI
Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer
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TLDR
In this paper, it was shown that 3T3-L1 adipocytes in obese mice exhibit increased reactive oxygen species (ROS) with lipid accumulation; the addition of free fatty acids elevates ROS generation further.About:
This article is published in Obesity Research & Clinical Practice.The article was published on 2013-09-01. It has received 493 citations till now. The article focuses on the topics: Type 2 diabetes & Metabolic syndrome.read more
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Mercury and metabolic syndrome: a review of experimental and clinical observations
Alexey A. Tinkov,Olga P. Ajsuvakova,Margarita G. Skalnaya,Elizaveta V. Popova,A. I. Sinitskii,Olga N. Nemereshina,Evgenia R. Gatiatulina,Alexandr A. Nikonorov,Anatoly V. Skalny,Anatoly V. Skalny +9 more
TL;DR: The reviewed data demonstrate that mercury affects universal pathogenetic mechanisms of MetS development, and it can be proposed that mercury may induce endoplasmic reticulum stress.
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Role of Magnesium in Oxidative Stress in Individuals with Obesity
Jennifer Beatriz Silva Morais,Juliana Soares Severo,Loanne Rocha dos Santos,Stéfany Rodrigues de Sousa Melo,Raisa de Oliveira Santos,Ana Raquel Soares de Oliveira,Kyria Jayanne Clímaco Cruz,Dilina do Nascimento Marreiro +7 more
TL;DR: A review of current research on the participation of magnesium in the oxidative stress present in obesity can help define the need for intervention with supplementation of this mineral for the prevention and treatment of disorders associated with this chronic disease.
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Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study
Shuang Zheng,Sheng Shi,Xingxing Ren,Tingting Han,Yangxue Li,Yawen Chen,Wei Liu,Peter C. Hou,Yaomin Hu +8 more
TL;DR: TyG-WC is a novel and clinically effective marker for early identifying the risks of prediabetes and diabetes in FDRs of T2DM patients and was further confirmed in the follow-up study.
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The Integrase Inhibitors Dolutegravir and Raltegravir Exert Proadipogenic and Profibrotic Effects and Induce Insulin Resistance in Human/Simian Adipose Tissue and Human Adipocytes
Jennifer Gorwood,Christine Bourgeois,Valérie Pourcher,Valérie Pourcher,Guillaume Pourcher,Frédéric Charlotte,Matthieu Mantecon,Cindy Rose,Romain Morichon,Michael Atlan,Roger Le Grand,Delphine Desjardins,Christine Katlama,Christine Katlama,Bruno Fève,Olivier Lambotte,Jacqueline Capeau,Véronique Béréziat,Claire Lagathu +18 more
TL;DR: Light is shed on the fat modifications observed in INSTI-treated HIV-infected individuals by using human and simian models to assess the impact of INSTIs on adipose tissue phenotype and function.
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Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep Apnea: A Possible Link to Oxidative Stress and Cardiovascular Complications.
TL;DR: The current review summarizes recent data on a possible link between leptin and oxidative stress in the pathogenesis of sleep breathing disorders and suggests Hyperleptinemia and leptin resistance may upregulate generation of reactive oxygen species, increasing oxidative stress and promoting inflammation.
References
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Hallmarks of cancer: the next generation.
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.