Journal ArticleDOI
Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.
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TLDR
Through bioassay-guided fractionation and chromatography technique, eight indole alkaloids were furnished from the stems of Ervatamia hainanensis, in which compounds 1 and 3 exhibited the same level of activities as galantamine, a marketed cholinesterase inhibitor for the treatment of Alzheimer's disease.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2010-11-01. It has received 53 citations till now. The article focuses on the topics: Indole alkaloid & Acetylcholinesterase.read more
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Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy
Ana Paula Murray,María Belén Faraoni,María Julia Castro,Natalia Paola Alza,Valeria Cavallaro +4 more
TL;DR: This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition.
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Advancement and prospects of bioinformatics analysis for studying bioactive peptides from food-derived protein: Sequence, structure, and functions
TL;DR: An overview of research progress in the bioinformatics methods used for identifying, characterizing, elaborating bioactive mechanisms of, and producing food-derived bioactive peptides is provided to present an effective workflow.
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Comparison of analytical techniques for the identification of bioactive compounds from natural products
TL;DR: Current techniques in phytochemical analysis and the identification of biologically active components are discussed, indicating the necessity for the development of a rapid method for the Identification of novel compounds from plant extracts.
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Ervatamines A-I, Anti-inflammatory Monoterpenoid Indole Alkaloids with Diverse Skeletons from Ervatamia hainanensis.
Dong-Bo Zhang,Dao-Geng Yu,Meng Sun,Xu-Xin Zhu,Xiaojun Yao,Shuang-Yan Zhou,Jian-Jun Chen,Kun Gao +7 more
TL;DR: Nine new monoterpenoid indole alkaloids, ervatamines A-I (1-9), and five known ones (10-14), were isolated from Ervatamia hainanensis, and the new structures were elucidated by extensive spectroscopic analysis and comparison to known compounds.
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Subtle Effects of Biological Invasions: Cellular and Physiological Responses of Fish Eating the Exotic Pest Caulerpa racemosa
Serena Felline,Roberto Caricato,Adele Cutignano,Stefania Gorbi,Maria Giulia Lionetto,Ernesto Mollo,Francesco Regoli,Antonio Terlizzi +7 more
TL;DR: Results of this study revealed that the entering of alien species in subtidal systems can alter trophic webs and can represent an important, indirect mechanism which might contribute to influence fluctuations of fish stocks and, also, the effectiveness of protection regimes.
References
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Journal ArticleDOI
A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
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The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
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Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
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Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
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The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development
TL;DR: Cholinergic abnormalities may also contribute to noncognitive behavioral abnormalities as well as the deposition of toxic neuritic plaques in AD and cholinergic-based strategies will likely remain valid as one approach to rational drug development for the treatment of AD other forms of dementia.