Influenza A Virus M2 Protein: Roles from Ingress to Egress
TLDR
This review discusses M2 protein synthesis and assembly into an ion channel, its roles in IAV replication, and the pathophysiological impact on the host cell.Abstract:
Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence extensively studied, ion channel proteins. The M2 ion channel activity is not only essential for virus replication, but also involved in modulation of cellular homeostasis in a variety of ways. It is also the target for ion channel inhibitors, i.e., anti-influenza drugs. Thus far, several studies have been conducted to elucidate its biophysical characteristics, structure-function relationships of the ion channel, and the M2-host interactome. In this review, we discuss M2 protein synthesis and assembly into an ion channel, its roles in IAV replication, and the pathophysiological impact on the host cell.read more
Citations
More filters
Journal ArticleDOI
M2e-based universal influenza vaccines: a historical overview and new approaches to development.
TL;DR: A historical overview of the study of the M2 protein, and the latest developments in the preparation of M2e-based universal influenza vaccines are summarized.
Journal ArticleDOI
Detection Methods of Human and Animal Influenza Virus—Current Trends
TL;DR: The basic affairs connected to the influenza virus were reviewed, highlighting the newest trends in its diagnostic methods, and various novel detection methods, such as electrical and optical were compared.
Journal ArticleDOI
Overview of HCV Life Cycle with a Special Focus on Current and Possible Future Antiviral Targets.
TL;DR: The functions of the different targets of current DAAs, the mode of action of these DAAs and potential future inhibitors are described.
Journal ArticleDOI
Long Noncoding RNA Lnc-MxA Inhibits Beta Interferon Transcription by Forming RNA-DNA Triplexes at Its Promoter.
Xinda Li,Guijie Guo,Min Lu,Wenjia Chai,Yucen Li,Xiaomei Tong,Jing Li,Xiaojuan Jia,Wenjun Liu,Dandan Qi,Xin Ye +10 more
TL;DR: This study revealed that lnc-MxA is an interferon-stimulated gene (ISG) that negatively regulates the transcription of IFN-β by forming an RNA-DNA triplex in a manner similar to that of a negative regulator of the antiviral immune response.
Journal ArticleDOI
Microtubules in Influenza Virus Entry and Egress.
Caitlin Simpson,Yohei Yamauchi +1 more
TL;DR: Microtubules, their functional roles in normal cell biology, and their exploitation by influenza viruses will be the focus of this review.
References
More filters
Journal ArticleDOI
WebLogo: A Sequence Logo Generator
TL;DR: WebLogo generates sequence logos, graphical representations of the patterns within a multiple sequence alignment that provide a richer and more precise description of sequence similarity than consensus sequences and can rapidly reveal significant features of the alignment otherwise difficult to perceive.
Journal ArticleDOI
Sequence logos: a new way to display consensus sequences
Thomas D. Schneider,R M Stephens +1 more
TL;DR: From these 'sequence logos', one can determine not only the consensus sequence but also the relative frequency of bases and the information content at every position in a site or sequence.
Journal ArticleDOI
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
John J. Skehel,Don C. Wiley +1 more
TL;DR: Comparisons to the soluble N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) protein complex of vesicle fusion suggests that these molecules are all in the fusion-activated conformation and that the juxtaposition of the membrane anchor and fusion peptide, a recurring feature, is involved in the fused mechanism.
Journal ArticleDOI
Inflammasomes: mechanism of action, role in disease, and therapeutics
TL;DR: Increasing evidence in mouse models strongly implicates an involvement of the inflammasome in the initiation or progression of diseases with a high impact on public health, such as metabolic disorders and neurodegenerative diseases.
Journal ArticleDOI
Endosome maturation: Endosome maturation
Jatta Huotari,Ari Helenius +1 more
TL;DR: The maturation programme entails a dramatic transformation of these dynamic organelles disconnecting them functionally and spatially from early endosomes and preparing them for their unidirectional role as a feeder pathway to lysosomes.