Journal ArticleDOI
Inhibition of epidermal growth factor binding to surface receptors by tumor promotors.
TLDR
The results suggest that TPA does not bind directly to EGF receptors, and interacts synergistically with EGF in stimulating glycolysis and DNA synthesis in 3T3 cells.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1979-02-28. It has received 176 citations till now. The article focuses on the topics: Epidermal growth factor & Growth factor receptor inhibitor.read more
Citations
More filters
Journal ArticleDOI
Epidermal growth factor
TL;DR: The EGF-MolecularWeight Form of mEGF and the Synthesis of Extracellular Macromolecules, and the Biological Effects of EGF and Urogastrone are presented.
Journal ArticleDOI
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
D Toullec,P Pianetti,H Coste,P Bellevergue,T Grand-Perret,M Ajakane,V Baudet,P Boissin,E Boursier,F Loriolle +9 more
TL;DR: GF 109203X was a competitive inhibitor with respect to ATP and displayed high selectivity for PKC as compared to five different protein kinases, illustrating the potential of this compound as a tool for studying the involvement of PKC in signal transduction pathways.
Journal ArticleDOI
Early signals in the mitogenic response
TL;DR: Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts are integrated in a unified hypothesis for the regulation of fibroblast growth.
Journal ArticleDOI
Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound
TL;DR: A single topical application of benzoyl peroxide produced a marked epidermal hyperplasia and induced a large number of dark basal keratinocytes, effects similar to those produced by the potent tumor promoter 12-O-tetradecanoyl phorbol-13-acetate.
Book ChapterDOI
Tumor promoters and the mechanism of tumor promotion.
TL;DR: This chapter reviews the studies on the mechanism of tumor promotion in mouse skin by croton oil and phorbol diesters and on the effects of these compounds on cell cultures of various types and discusses the findings in the field of tumor promoters during mid- 1979.
References
More filters
Journal ArticleDOI
125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.
TL;DR: The data are consistent with a mechanism in which 125I-hEGF initially is bound to the cell surface and subsequently is internlized before degradation, and the binding capacity of these cells is restored by incubation in a serum-containing medium.
Journal ArticleDOI
Enzymatic iodination of polypeptides with 125I to high specific activity.
J.I. Thorell,B.G. Johansson +1 more
TL;DR: Polypeptide hormones radioiodinated by this technique retained their immunological reactivity and were used in radioimmunoassays with good results.
Journal ArticleDOI
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.
C. Richard Savage,Stanley Cohen +1 more
TL;DR: A new procedure has been devised for the preparation of pure epidermal growth factor in high yield through a two-step column fractionation of crude extracts of the submaxillary gland obtained from adult male mice.
Journal ArticleDOI
Membrane receptors for hormones and neurotransmitters.
TL;DR: Investigation of the hormone- receptor interaction will no doubt yield new insights into both the mechanism of hormone action and membrane structure and function.
Journal ArticleDOI
Specific binding of phorbol ester tumor promoters.
TL;DR: The data suggest that biological responses to thephorbol esters in chicken embryo fibroblasts are mediated by this binding activity and that the binding activity corresponds to the phorbol Ester target in mouse skin involved in tumor promotion.
Related Papers (5)
Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.
C. Richard Savage,Stanley Cohen +1 more