Injectable Magnetic-Responsive Short-Peptide Supramolecular Hydrogels: Ex Vivo and In Vivo Evaluation.
Mari C. Mañas-Torres,Cristina Gila-Vilchez,Francisco J Vazquez-Perez,Pavel Kuzhir,David Momier,Jean-Claude Scimeca,Arnaud Borderie,Marianne Goracci,Fanny Burel-Vandenbos,Cristina Blanco-Elices,Ismael Rodríguez,Ismael Rodríguez,Miguel Alaminos,Luis Álvarez de Cienfuegos,Modesto T. López-López +14 more
TLDR
In this article, the behavior of biocompatible and biodegradable hydrogels made with Fmoc-diphenylalanine (Fmoc)-FF) and RGD short peptides to which MNP were incorporated was studied in detail with physicochemical, mechanical, and biological methods.Abstract:
The inclusion of magnetic nanoparticles (MNP) in a hydrogel matrix to produce magnetic hydrogels has broadened the scope of these materials in biomedical research. Embedded MNP offer the possibility to modulate the physical properties of the hydrogel remotely and on demand by applying an external magnetic field. Moreover, they enable permanent changes in the mechanical properties of the hydrogel, as well as alterations in the micro- and macroporosity of its three-dimensional (3D) structure, with the associated potential to induce anisotropy. In this work, the behavior of biocompatible and biodegradable hydrogels made with Fmoc-diphenylalanine (Fmoc-FF) (Fmoc = fluorenylmethoxycarbonyl) and Fmoc-arginine-glycine-aspartic acid (Fmoc-RGD) short peptides to which MNP were incorporated was studied in detail with physicochemical, mechanical, and biological methods. The resulting hybrid hydrogels showed enhance mechanical properties and withstood injection without phase disruption. In mice, the hydrogels showed faster and improved self-healing properties compared to their nonmagnetic counterparts. Thanks to these superior physical properties and stability during culture, they can be used as 3D scaffolds for cell growth. Additionally, magnetic short-peptide hydrogels showed good biocompatibility and the absence of toxicity, which together with their enhanced mechanical stability and excellent injectability make them ideal biomaterials for in vivo biomedical applications with minimally invasive surgery. This study presents a new approach to improving the physical and mechanical properties of supramolecular hydrogels by incorporating MNP, which confer structural reinforcement and stability, remote actuation by magnetic fields, and better injectability. Our approach is a potential catalyst for expanding the biomedical applications of supramolecular short-peptide hydrogels.read more
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Self-Assembled Peptide Nanostructures for ECM Biomimicry
TL;DR: This Review will analyze the last 5-year progress on the incorporation of bioactive motifs into self-assembling peptides to mimic functional proteins of the extracellular matrix and guide cell fate inside hydrogel scaffolds.
Journal ArticleDOI
Chirality-Induced Spin Selectivity in Heterochiral Short-Peptide-Carbon-Nanotube Hybrid Networks: Role of Supramolecular Chirality.
Md. Wazedur Rahman,Mari C. Mañas-Torres,Seyedamin Firouzeh,Sara Illescas‐Lopez,Juan M. Cuerva,Modesto T. López-López,Luis Álvarez de Cienfuegos,Sandipan Pramanik +7 more
TL;DR: Heterochiral carbon-nanotube-short-peptide materials made by the combination of two different chiral sources are developed, showing that the presence of a small amount of glucono-δ-lactone with fixed chirality can alter the supramolecular chiralities of the medium, thereby modulating the sign of the spin signal from "up" to "down" and vice versa.
Journal ArticleDOI
4D Printing of Hydrogels: Innovation in Material Design and Emerging Smart Systems for Drug Delivery
TL;DR: An overview of innovation in material design for smart hydrogel systems, current technical approaches toward 4D printing, and emerging 4D printed novel structures for drug delivery applications is provided.
Journal ArticleDOI
Self-assembly in magnetic supramolecular hydrogels
Cristina Gila-Vilchez,Laura Rodríguez-Arco,Mari C. Mañas-Torres,Luis Álvarez de Cienfuegos,Modesto T. López-López +4 more
TL;DR: In this paper , the role of magnetic nanoparticles in the self-assembly process of magnetic supramolecular hydrogels is discussed, as well as the applications of these materials in biomedical and biotechnological applications.
Journal ArticleDOI
A Rapid Self-Assembly Peptide Hydrogel for Recruitment and Activation of Immune Cells
Ruyue Luo,Yuan Wan,Xinyi Luo,Guicen Liu,Zhaoxu Li,Jialei Chen,Di Su,Naiomi Lu,Zhong-Sheng Luo +8 more
TL;DR: The characterization, biocompatibility, controlled release effect on antigen, immune cell recruitment ability, and antitumor properties of a self-assembly peptide named DRF3, which provide a reliable basis for the application of peptide hydrogels in biomedical and preclinical trials.
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