Journal ArticleDOI
Injectable PLGA porous beads cellularized by hAFSCs for cellular cardiomyoplasty
Chieh-Cheng Huang,Hao-Ji Wei,Yi-Chun Yeh,Jiun-Jie Wang,Jiun-Jie Wang,Wei-Wen Lin,Ting-Yin Lee,Shiaw-Min Hwang,Sung Wook Choi,Younan Xia,Yen Chang,Hsing-Wen Sung +11 more
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TLDR
The results of echocardiography, magnetic resonance imaging, and histological analyses suggest that the transplantation of hAFSC beads into an infarcted heart could effectively maintain its gross morphology, prevent successive ventricular expansion, and thereby improve the post-infarCTed cardiac function.About:
This article is published in Biomaterials.The article was published on 2012-06-01. It has received 69 citations till now. The article focuses on the topics: Transplantation.read more
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Electrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals
Radhakrishnan Sridhar,Rajamani Lakshminarayanan,Kalaipriya Madhaiyan,Veluchamy A. Barathi,Keith Hsiu Chin Lim,Seeram Ramakrishna +5 more
TL;DR: This review focuses on the nanoformulation of natural materials via the electrospraying or electrospinning of nanoparticles or nanofibers for tissue engineering or drug delivery/pharmaceutical purposes and classify the natural materials with respect to their animal/plant origin and macrocyclic, small molecule or herbal active constituents.
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Electrical coupling of isolated cardiomyocyte clusters grown on aligned conductive nanofibrous meshes for their synchronized beating
Chun-Wen Hsiao,Meng-Yi Bai,Yen Chang,Min-Fan Chung,Ting-Yin Lee,Cheng-Tse Wu,Barnali Maiti,Zi-Xian Liao,Ren-Ke Li,Hsing-Wen Sung +9 more
TL;DR: A mesh, consisting of aligned composite nanofibers of polyaniline and poly(lactic-co-glycolic acid) (PLGA), is developed as an electrically active scaffold for coordinating the beatings of the cultured cardiomyocytes synchronously, improving the impaired heart function.
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Biomaterials for cell transplantation
TL;DR: This Review discusses how biomaterial design strategies can be used to improve cell survival, influence the fate of transplanted cells, and favourably manipulate the host microenvironment and the immune system.
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Electrosprayed nanoparticles for drug delivery and pharmaceutical applications.
TL;DR: This report attempted to consolidate the reports pertaining to electrospraying and their corresponding therapeutic application area.
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Heart regeneration after myocardial infarction using synthetic biomaterials
TL;DR: The advances made in the last 10 years in the emerging field of cardiac repair using biomaterial-based delivery systems are discussed with focus on the progress made on preclinical in vivo studies and how the incorporation of both cells and proteins together into biomaterials has opened new horizons in the myocardial infarction treatment.
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Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
Michael A. Laflamme,Kent Chen,Anna V. Naumova,Veronica Muskheli,James A. Fugate,Sarah K. Dupras,Hans Reinecke,Chunhui Xu,Mohammad Hassanipour,Chris O'Sullivan,Lila R. Collins,Yinhong Chen,Elina Minami,Edward A. Gill,Shuichi Ueno,Chun Yuan,Joseph K. Gold,Charles E. Murry +17 more
TL;DR: This work generated highly purified human cardiomyocytes using a readily scalable system for directed differentiation that relies on activin A and BMP4, and identified a cocktail of pro-survival factors that limitsCardiomyocyte death after transplantation.
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Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
TL;DR: The potential paracrine mechanisms involved in adult stem cell signaling and therapy are reviewed: cytokines and growth factors can induce cytoprotection and neovascularization, and cardiac remodeling, contractility, and metabolism may also be influenced in aParacrine fashion.
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Isolation of amniotic stem cell lines with potential for therapy.
Paolo De Coppi,Georg Bartsch,M. Minhaj Siddiqui,Tao Xu,Cesar C. Santos,Laura Perin,Gustavo Mostoslavsky,Ang line C. Serre,Evan Y. Snyder,James J. Yoo,Mark E. Furth,Shay Soker,Anthony Atala +12 more
TL;DR: The isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express embryonic and adult stem cell markers are reported and examples of differentiated cells derived from human AFS cells and displaying specialized functions include neuronal lineage cells secreting the neurotransmitter L-glutamate or expressing G-protein-gated inwardly rectifying potassium channels.
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Vascularization in tissue engineering
TL;DR: It is illustrated that combining the efforts of different research lines might be necessary to obtain optimal results in the field of tissue engineering, and the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs are discussed.
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Regenerating the heart.
TL;DR: Future research is likely to focus on improving the ability to guide the differentiation of stem cells, control their survival and proliferation, identify factors that mediate their homing and modulate the heart's innate inflammatory and fibrotic responses.