Interindividual variability and lateralization of µ-opioid receptors in the human brain
Tatu Kantonen,Tomi Karjalainen,Tomi Karjalainen,Janne Isojärvi,Pirjo Nuutila,Pirjo Nuutila,Jouni Tuisku,Juha O. Rinne,Juha O. Rinne,Jarmo Hietala,Jarmo Hietala,Valtteri Kaasinen,Valtteri Kaasinen,Kari K. Kalliokoski,Harry Scheinin,Jussi Hirvonen,Aki Vehtari,Lauri Nummenmaa +17 more
TLDR
In vivo MOR availability in the brains of 204 individuals with no neurologic or psychiatric disorders is quantified using positron emission tomography (PET) with tracer [11C]carfentanil and Bayesian hierarchical modeling to estimate the effects of sex, age, body mass index (BMI) and smoking on [11Cs)carfENTanil binding potential.Abstract:
The brain9s mu-opioid receptors (MORs) are involved in analgesia, reward and mood regulation. Several neuropsychiatric diseases have been associated with dysfunctional MOR system, and there is also considerable variation in receptor density among healthy individuals. Sex, age, body mass and smoking have been proposed to influence the MOR system, but due to small sample sizes the magnitude of their influence remains inconclusive. Here we quantified in vivo MOR availability in the brains of 204 individuals with no neurologic or psychiatric disorders using positron emission tomography (PET) with tracer [11C]carfentanil. We then used Bayesian hierarchical modeling to estimate the effects of sex, age, body mass index (BMI) and smoking on [11C]carfentanil binding potential. We also examined hemispheric lateralization of MOR availability. Age had regionally specific effects on MOR availability, with age-dependent increase in frontotemporal areas but decrease in amygdala, thalamus, and nucleus accumbens. The age-dependent increase was stronger in males. MOR availability was globally lowered in smokers but independent of BMI. Finally, MOR availability was higher in the right versus the left hemisphere. The presently observed variation in MOR availability may explain why some individuals are prone to develop MOR-linked pathological states, such as chronic pain or psychiatric disorders.read more
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neuromaps: structural and functional interpretation of brain maps
Ross D. Markello,Justine Y. Hansen,Zhen-Qi Liu,Vincent Bazinet,Golia Shafiei,Laura E. Suárez,Nadia Blostein,Jakob Seidlitz,S Baillet,Theodore D. Satterthwaite,M. Mallar Chakravarty,Armin Raznahan,Bratislav Misic +12 more
TL;DR: Neuralomaps as mentioned in this paper is a toolbox for accessing, transforming and analyzing structural and functional brain annotations, which includes curated reference maps and biological ontologies of the human brain, such as molecular, microstructural, electrophysiological, developmental and functional ontologies.
Journal ArticleDOI
Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety
Lauri Nummenmaa,Lauri Nummenmaa,Tomi Karjalainen,Janne Isojärvi,Tatu Kantonen,Tatu Kantonen,Jouni Tuisku,Valtteri Kaasinen,Valtteri Kaasinen,Juho Joutsa,Juho Joutsa,Pirjo Nuutila,Pirjo Nuutila,Kari K. Kalliokoski,Jussi Hirvonen,Jussi Hirvonen,Jarmo Hietala,Juha O. Rinne +17 more
TL;DR: It is concluded that dysregulated MOR availability is involved in altered mood and pathophysiology of depression and anxiety disorders.
Journal ArticleDOI
Adult Attachment System Links With Brain Mu Opioid Receptor Availability In Vivo.
Otto Turtonen,Aino Saarinen,Lauri Nummenmaa,Lauri Tuominen,Maria Tikka,Reetta-Liina Armio,Airi Hautamäki,Heikki Laurikainen,Olli T. Raitakari,Liisa Keltikangas-Järvinen,Jarmo Hietala +10 more
TL;DR: Preliminary in vivo evidence is provided that the opioid system may be involved in the neurocircuits associated with individual differences in adult attachment behavior and suggests variation in mu opioid receptor availability may be linked with the individuals' social relationships and psychosocial well-being and thus contributes to risk for psychiatric morbidity.
Journal ArticleDOI
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities
Justine Y. Hansen,Golia Shafiei,Jacob W. Vogel,Kelly Smart,Carrie E. Bearden,Martine Hoogman,Barbara Franke,Daan van Rooij,Jan K. Buitelaar,Carrie R. McDonald,Sanjay M. Sisodiya,Lianne Schmaal,Dick J. Veltman,Odile A. van den Heuvel,Dan J. Stein,Theo G.M. van Erp,Christopher R.K. Ching,Ole A. Andreassen,Tomas Hajek,Nils Opel,Gemma Modinos,André Aleman,Ysbrand D. van der Werf,Neda Jahanshad,Sophia I. Thomopoulos,Paul M. Thompson,Richard E. Carson,Alain Dagher,Bratislav Misic +28 more
TL;DR: Using MRI morphometry from the ENIGMA consortium, the authors constructed maps of cortical abnormalities for thirteen neurodevelopmental, neurological, and psychiatric disorders from N = 21,000 participants and N = 26,000 controls, collected using a harmonised processing protocol.
Posted ContentDOI
Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities
Justine Y. Hansen,Golia Shafiei,Jacob W. Vogel,Kelly Smart,Carrie E. Bearden,Martine Hoogman,Barbara Franke,Daan van Rooij,Jan K. Buitelaar,Carrie R. McDonald,Sanjay M. Sisodiya,Lianne Schmaal,Dick J. Veltman,Odile A. van den Heuvel,Dan J. Stein,Theo G.M. van Erp,Christopher R.K. Ching,Ole A. Andreassen,Tomas Hajek,Nils Opel,Gemma Modinos,André Aleman,Ysbrand D. van der Werf,Neda Jahanshad,Sophia I. Thomopoulos,Paul M. Thompson,Richard E. Carson,Alain Dagher,Bratislav Misic +28 more
TL;DR: In this article , the authors systematically compare cortical maps to multiple micro-architectural measures, including gene expression, neurotransmitter density, metabolism, and myelination, as well as global connectomic measures including number of connections, centrality, and connection diversity (connectomic vulnerability).
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