Interplay Between Long-Range And Short-Range Interactions In Polymer Self-Assembly And Cell Adhesion
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In this paper, reversible gelation of associating polymers and ligand-receptor interactions in membrane adhesion was studied, and the energy barrier of the adhesion as a result of membrane bending deformations and the double-well adhesion potential was calculated.Abstract:
Interplay between long-range and short-range interactions is a common theme in soft and biological matter, which results in complicated self-assembly behaviors. We study two examples of this interplay: reversible gelation of associating polymers and ligand-receptor interactions in membrane adhesion. In associating polymer solutions, the competition between the conformation flexibility of polymer chains and the enthalpic monomer interactions results in phase-separated micro-structures at the mesoscopic scale; both gelation and the microphase order-disorder transition are manifestations of this self-assembly. We further establish that reversible gelation is similar to the glass transition: both are characterized by ergodicity breaking, aperiodic micro-structures, and non-equilibrium relaxations over a finite temperature range. In the study of ligand-receptor interactions between surfaces, we emphasize the interplay between specific ligand-receptor binding, and generic physical interactions. We find that both the finite spatial extension of receptors and their mobilities affect their binding affinity. As a special case of the interplay between receptor binding and generic interactions, we study the dynamics of membrane adhesion that is mediated by receptor binding but fulfilled through membrane deformations. We calculate the energy barrier of the adhesion as a result of membrane bending deformations and the double-well adhesion potential, and analyze the different scenarios according to the shape of the adhesion potential by scaling arguments.read more
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Journal Article
Cell Adhesion as Dynamic Interplay of Lock-and-Key, Generic and Elastic Forces(Physics of Non-Equilibrium Systems: Self-Organized Structures and Dynamics Far from Equilibrium)
TL;DR: The selectivity of cell-cell and cell-tissue adhesion is determined by specific short range forces between cell surface proteins, which function as constraint reaction spaces facilitating the local assembly of actin stress fibers and control cell signalling processes.
Journal ArticleDOI
Cell Adhesion as Dynamic Interplay of Lock-and-Key, Generic and Elastic Forces
TL;DR: The selectivity of cell-cell and cell-tissue adhesion is determined by specific short range forces between cell surface proteins as mentioned in this paper, which serve the fine control of the strength and duration of adhesion.
Journal ArticleDOI
Influence of tether dynamics on forced Kramers escape from a kinetic trap.
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TL;DR: This work solves the full Kramers escape problem for the coupled system using a technique attributed to Langer, and shows that the prefactor in the escape rate is significantly modified by the spring parameters even in the strong-damping limit.
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First- and second-order transitions in models with a continuous set of energy minima
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Polymer-tethered ligand–receptor interactions between surfaces
TL;DR: From statistical thermodynamics calculations, an effective two-dimensional binding constant is obtained reflecting contributions from the microscopic binding affinity as well as from the conformation entropy of the polymer tethers.