Interplay Between Long-Range And Short-Range Interactions In Polymer Self-Assembly And Cell Adhesion
TLDR
In this paper, reversible gelation of associating polymers and ligand-receptor interactions in membrane adhesion was studied, and the energy barrier of the adhesion as a result of membrane bending deformations and the double-well adhesion potential was calculated.Abstract:
Interplay between long-range and short-range interactions is a common theme in soft and biological matter, which results in complicated self-assembly behaviors. We study two examples of this interplay: reversible gelation of associating polymers and ligand-receptor interactions in membrane adhesion. In associating polymer solutions, the competition between the conformation flexibility of polymer chains and the enthalpic monomer interactions results in phase-separated micro-structures at the mesoscopic scale; both gelation and the microphase order-disorder transition are manifestations of this self-assembly. We further establish that reversible gelation is similar to the glass transition: both are characterized by ergodicity breaking, aperiodic micro-structures, and non-equilibrium relaxations over a finite temperature range. In the study of ligand-receptor interactions between surfaces, we emphasize the interplay between specific ligand-receptor binding, and generic physical interactions. We find that both the finite spatial extension of receptors and their mobilities affect their binding affinity. As a special case of the interplay between receptor binding and generic interactions, we study the dynamics of membrane adhesion that is mediated by receptor binding but fulfilled through membrane deformations. We calculate the energy barrier of the adhesion as a result of membrane bending deformations and the double-well adhesion potential, and analyze the different scenarios according to the shape of the adhesion potential by scaling arguments.read more
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References
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Journal ArticleDOI
Effect of bilayer thickness on membrane bending rigidity.
TL;DR: The bending rigidity k(c) of bilayer vesicles self-assembled from amphiphilic diblock copolymers has been measured using single- and dual-micropipet techniques and is found to be nearly quadratic, in good agreement with existing theories for bilayer membranes.
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Adhesion-induced domain formation by interplay of long-range repulsion and short-range attraction force: a model membrane study
TL;DR: It is demonstrated that adhesion is accompanied by lateral phase separation, leading to the formation of domains of tight adhesion (adhesion plaques) separated by areas of weak adhesion exhibiting pronounced flickering.
Journal ArticleDOI
Optimizing chain bridging in complex block copolymers
TL;DR: In this paper, the authors developed a computational tool for evaluating average bridging fractions of internal blocks in complex block copolymers and applied the tool to the optimization of bridging fraction in mesophase structures computed with self-consistent field theory.
Journal ArticleDOI
The aperiodic crystal picture and free energy barriers in glasses
Randall W. Hall,Peter G. Wolynes +1 more
TL;DR: In this paper, the aperiodic crystal picture associates the glass transition with freezing into a nonperiodic structure, and activation barriers may be estimated through the use of freezing theory and the theory of dense solids.
Journal ArticleDOI
Stripe glasses: self-generated randomness in a uniformly frustrated system
Joerg Schmalian,Peter G. Wolynes +1 more
TL;DR: In this paper, a system with competing interactions on different length scales, relevant to the formation of stripes in doped Mott insulators, undergoes a self-generated glass transition which is caused by the frustrated nature of the interactions and not related to the presence of quenched disorder.