Journal ArticleDOI
The immunological synapse: A molecular machine controlling T cell activation
About:
This article is published in Transfusion Medicine Reviews.The article was published on 2000-01-01. It has received 554 citations till now. The article focuses on the topics: Immunological synapse & T cell.read more
Citations
More filters
Journal ArticleDOI
Polymer-supported membranes as models of the cell surface
TL;DR: This work focuses on lipid-bilayer membranes supported on solid substrates, which are widely used as cell-surface models that connect biological and artificial materials and when these systems are coupled with advanced semiconductor technology.
Journal ArticleDOI
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes.
Zuoming Sun,Christopher Arendt,Wilfried Ellmeier,Wilfried Ellmeier,Edward M. Schaeffer,Edward M. Schaeffer,Mary Jean Sunshine,Mary Jean Sunshine,Leena Gandhi,Justin P. Annes,Daniela Petrzilka,Daniela Petrzilka,Abraham Kupfer,Pamela L. Schwartzberg,Dan R. Littman,Dan R. Littman +15 more
TL;DR: The results indicate that PKC-θ functions in a unique pathway that links the TCR signalling complex to the activation of NF-κB in mature T lymphocytes, and induction of JNK was normal in T cells from mutant mice.
Journal ArticleDOI
Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.
Adam D. Douglass,Ronald D. Vale +1 more
TL;DR: It is shown that the coreceptor CD2, the adaptor protein LAT, and tyrosine kinase Lck cocluster in discrete microdomains in the plasma membrane of signaling T cells, which require protein-protein interactions mediated through phosphorylation of LAT and are not maintained by interactions with actin or lipid rafts.
Journal ArticleDOI
The who, how and where of antigen presentation to B cells.
TL;DR: This Review summarize studies that have used high-resolution imaging approaches to visualize antigen presentation to B cells in secondary lymphoid organs that illustrate that encounters of B cells with antigen in these organs can be facilitated by diffusion of the antigen or by the presentation of antigen by macrophages, dendritic cells and follicular dendsritic cells.
Journal ArticleDOI
Signal transduction by cell adhesion receptors and the cytoskeleton : functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members
TL;DR: Insight is provided into mechanisms underlying the ability of integrins, cadherins, selectins, and other cell adhesion molecules to regulate signal transduction cascades that permit the efficient flow of information in signaling pathways.
References
More filters
Journal ArticleDOI
Polymer-supported membranes as models of the cell surface
TL;DR: This work focuses on lipid-bilayer membranes supported on solid substrates, which are widely used as cell-surface models that connect biological and artificial materials and when these systems are coupled with advanced semiconductor technology.
Journal ArticleDOI
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes.
Zuoming Sun,Christopher Arendt,Wilfried Ellmeier,Wilfried Ellmeier,Edward M. Schaeffer,Edward M. Schaeffer,Mary Jean Sunshine,Mary Jean Sunshine,Leena Gandhi,Justin P. Annes,Daniela Petrzilka,Daniela Petrzilka,Abraham Kupfer,Pamela L. Schwartzberg,Dan R. Littman,Dan R. Littman +15 more
TL;DR: The results indicate that PKC-θ functions in a unique pathway that links the TCR signalling complex to the activation of NF-κB in mature T lymphocytes, and induction of JNK was normal in T cells from mutant mice.
Journal ArticleDOI
TFOS DEWS II Management and Therapy Report
Lyndon Jones,Laura E Downie,Donald R. Korb,Jose M. Benitez-del-Castillo,Reza Dana,Sophie X. Deng,Pham N. Dong,Gerd Geerling,Richard Y Hida,Yang Liu,Kyoung Yul Seo,Joseph Tauber,Tais Hitomi Wakamatsu,Jianjiang Xu,James S. Wolffsohn,Jennifer P. Craig +15 more
TL;DR: It became clear that many of the treatments available for the management of dry eye disease lack the necessary Level 1 evidence to support their recommendation, often due to a lack of appropriate masking, randomization or controls and in some cases due to issues with selection bias or inadequate sample size.
Journal ArticleDOI
Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.
Adam D. Douglass,Ronald D. Vale +1 more
TL;DR: It is shown that the coreceptor CD2, the adaptor protein LAT, and tyrosine kinase Lck cocluster in discrete microdomains in the plasma membrane of signaling T cells, which require protein-protein interactions mediated through phosphorylation of LAT and are not maintained by interactions with actin or lipid rafts.
Journal ArticleDOI
The who, how and where of antigen presentation to B cells.
TL;DR: This Review summarize studies that have used high-resolution imaging approaches to visualize antigen presentation to B cells in secondary lymphoid organs that illustrate that encounters of B cells with antigen in these organs can be facilitated by diffusion of the antigen or by the presentation of antigen by macrophages, dendritic cells and follicular dendsritic cells.