Interplay between tight junctions & adherens junctions.
TLDR
This review will first describe the individual components of both the adherens and tight junctions and then discuss the coupling of the two complexes with an emphasis on the signaling links and physical interactions between the two junctional complexes.About:
This article is published in Experimental Cell Research.The article was published on 2017-09-01 and is currently open access. It has received 183 citations till now. The article focuses on the topics: Adherens junction & Septate junctions.read more
Citations
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Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.
TL;DR: This review discusses the current state-of-the-art of biomembrane simulations that, until now, have largely focused on a rather narrow picture of the complexity of the membranes, and discusses the challenges that should unravel in the foreseeable future.
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Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions.
TL;DR: In this article, Gut epithelium is an efficient barrier that prevents the absorption of liposaccharide (LPS), which is an important factor in the development of many chronic diseases in animals and man.
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Targeting PVR (CD155) and its receptors in anti-tumor therapy.
Paola Kucan Brlic,Tihana Lenac Rovis,Guy Cinamon,Pini Tsukerman,Ofer Mandelboim,Stipan Jonjić +5 more
TL;DR: Increasing evidence supports the rationale for developing strategies targeting PVR interactions with activating and inhibitory immune cell receptors, either in terms of checkpoint therapy or in adoptive cell therapy, which targets PVR as a tumor marker.
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Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation
Hana Fakhoury,Peter R. Kvietys,Wael Al-Kattan,Fatme Al Anouti,Muhammad Affan Elahi,Spyridon N. Karras,William B. Grant +6 more
TL;DR: The importance of vitamin D/VDR signaling in intestinal homeostasis is evidenced by the development of a chronic inflammatory state (e.g. IBD) when this signaling system is disrupted.
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High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function
Inna Grosheva,Danping Zheng,Danping Zheng,Maayan Levy,Maayan Levy,Omer Polansky,Alexandra Lichtenstein,Ofra Golani,Mally Dori-Bachash,Claudia Moresi,Hagit Shapiro,Sara Del Mare-Roumani,Rafael Valdes-Mas,Yiming He,Yiming He,Hodaya Karbi,Minhu Chen,Alon Harmelin,Ravid Straussman,Nissan Yissachar,Eran Elinav,Benjamin Geiger +21 more
TL;DR: Molecules that disrupt and stabilize intestinal epithelial TJs and barrier function and affect development of colon inflammation in mice are identified and might be developed for treatment of barrier intestinal impairment-associated and inflammatory disorders in patients, or avoided to prevent inflammation.
References
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Occludin: a novel integral membrane protein localizing at tight junctions.
TL;DR: An integral membrane protein localizing at tight junctions is now identified, which is designated as "occludin," which was revealed by a hydrophilicity plot that was very similar to that of connexin, an integral membraneprotein in gap junctions.
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Convergence of Wnt, ß-Catenin, and Cadherin Pathways
W. James Nelson,Roel Nusse +1 more
TL;DR: Evidence is assembled of possible interrelations between Wnt and other growth factor signaling, β-catenin functions, and cadherin-mediated adhesion in tissue differentiation.
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The tight junction: a multifunctional complex.
TL;DR: A group of integral membrane proteins-occludin, claudins, and junction adhesion molecules-interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity.
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Directed actin polymerization is the driving force for epithelial cell-cell adhesion.
TL;DR: A dynamic mechanism for intercellular adhesion is unveiled involving calcium-activated filopodia penetration and VASP/Mena-dependent actin reorganization/polymerization.
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Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins
TL;DR: Detailed analyses showed that ZO-2 andZO-3 are recruited to the claudin-based networks through PDZ1 and PDZ2 domains of Z o-1/Zo-2/Z o-3 were also recruited to claudIn-based TJs, when introduced into cultured epithelial cells.
Related Papers (5)
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
Andrea Hartsock,W. James Nelson +1 more