Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases
TLDR
In this paper, the authors focused on the connection between miRNAs, RNA-binding proteins (RBPs), and neurodegenerative diseases, and showed that RBPs were shown to play a critical role in regulating miRNA biogenesis and metabolism, and the data about the interplay among RBPs and miRNA and their cooperation in brain functions would be important to know for better understanding NDs and the development of effective therapeutics.Abstract:
The number of patients with neurodegenerative diseases (NDs) is increasing, along with the growing number of older adults. This escalation threatens to create a medical and social crisis. NDs include a large spectrum of heterogeneous and multifactorial pathologies, such as amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and multiple system atrophy, and the formation of inclusion bodies resulting from protein misfolding and aggregation is a hallmark of these disorders. The proteinaceous components of the pathological inclusions include several RNA-binding proteins (RBPs), which play important roles in splicing, stability, transcription and translation. In addition, RBPs were shown to play a critical role in regulating miRNA biogenesis and metabolism. The dysfunction of both RBPs and miRNAs is often observed in several NDs. Thus, the data about the interplay among RBPs and miRNAs and their cooperation in brain functions would be important to know for better understanding NDs and the development of effective therapeutics. In this review, we focused on the connection between miRNAs, RBPs and neurodegenerative diseases.read more
Citations
More filters
Journal ArticleDOI
Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.
Doris Loh,Russel J. Reiter +1 more
TL;DR: The potential of melatonin in the modulation of biomolecular condensate in the attenuation of aberrant condensat aggregation in neurodegenerative disorders is discussed in this paper.
Journal ArticleDOI
Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR
Li Guo,Lin Jia,Lulu Luo,Xin-Ran Xu,Yangyang Xiang,Yujie Ren,Dekang Ren,Lulu Shen,Tingming Liang +8 more
TL;DR: The diverse roles of a circRNA-associated ceRNA network in cancer metastasis and the potential clinical application are summarized, especially the interaction of circRNA and miRNA/isomiR, which may complicate the RNA regulatory network and which will contribute to a novel insight into circRNA in the future.
Journal ArticleDOI
microRNA-146a-5p, Neurotropic Viral Infection and Prion Disease (PrD).
Aileen I. Pogue,Walter J. Lukiw +1 more
TL;DR: In this paper, the authors review the recent data supporting the idea that miRNA-146a may represent a novel and unique sncRNA-based biomarker for inflammatory neurodegeneration in multiple species.
Journal ArticleDOI
Fission Impossible: Stabilized miRNA-Based Analogs in Neurodegenerative Disease
TL;DR: Of exhibiting a specific down-regulation of brain-enriched miRNA in miRNA is a major in the most CA1 in CA1 studies.
Journal ArticleDOI
Advances in the study of RNA-binding proteins in diabetic complications
Xinyuan Chen,Jiaqiang Wu,Zhangwang Li,Jiashu Han,Panpan Xia,Yunfeng Shen,Jianyong Ma,Jing Zhang,Peng Yu +8 more
TL;DR: In this article , the authors summarized recent studies on the roles and mechanisms of RBPs in mediating abnormal gene expression in diabetes and its complications and discussed the potential and theoretical basis of RBP to treat diabetes and complications.
References
More filters
Journal ArticleDOI
Regulation of microRNA biogenesis
Minju Ha,V. Narry Kim +1 more
TL;DR: Small non-coding RNAs that function as guide molecules in RNA silencing are involved in nearly all developmental and pathological processes in animals and their dysregulation is associated with many human diseases.
Journal ArticleDOI
UniProt: the universal protein knowledgebase in 2021
Alex Bateman,Maria Jesus Martin,Sandra Orchard,Michele Magrane,Rahat Agivetova,Shadab Ahmad,Emanuele Alpi,Emily H Bowler-Barnett,Ramona Britto,Borisas Bursteinas,Hema Bye-A-Jee,Ray Coetzee,Austra Cukura,Alan Wilter Sousa da Silva,Paul Denny,Tunca Doğan,ThankGod Ebenezer,Jun Fan,Leyla Jael Garcia Castro,Penelope Garmiri,George Georghiou,Leonardo Gonzales,Emma Hatton-Ellis,Abdulrahman Hussein,Alexandr Ignatchenko,Giuseppe Insana,Rizwan Ishtiaq,Petteri Jokinen,Vishal Joshi,Dushyanth Jyothi,Antonia Lock,Rodrigo Lopez,Aurelien Luciani,Jie Luo,Yvonne Lussi,Alistair MacDougall,Fábio Madeira,Mahdi Mahmoudy,Manuela Menchi,Alok Mishra,Katie Moulang,Andrew Nightingale,Carla Susana Oliveira,Sangya Pundir,Guoying Qi,Shriya Raj,Daniel Rice,Milagros Rodriguez Lopez,Rabie Saidi,Joseph Sampson,Tony Sawford,Elena Speretta,Edward Turner,Nidhi Tyagi,Preethi Vasudev,Vladimir Volynkin,Kate Warner,Xavier Watkins,Rossana Zaru,Hermann Zellner,Alan Bridge,Sylvain Poux,Nicole Redaschi,Lucila Aimo,Ghislaine Argoud-Puy,Andrea H. Auchincloss,Kristian B. Axelsen,Parit Bansal,Delphine Baratin,Marie-Claude Blatter,Jerven Bolleman,Emmanuel Boutet,Lionel Breuza,Cristina Casals-Casas,Edouard de Castro,Kamal Chikh Echioukh,Elisabeth Coudert,Béatrice A. Cuche,M Doche,Dolnide Dornevil,Anne Estreicher,Maria Livia Famiglietti,Marc Feuermann,Elisabeth Gasteiger,Sebastien Gehant,Vivienne Baillie Gerritsen,Arnaud Gos,Nadine Gruaz-Gumowski,Ursula Hinz,Chantal Hulo,Nevila Hyka-Nouspikel,Florence Jungo,Guillaume Keller,Arnaud Kerhornou,Vicente Lara,Philippe Le Mercier,Damien Lieberherr,Thierry Lombardot,Xavier D. Martin,Patrick Masson,Anne Morgat,Teresa Batista Neto,Salvo Paesano,Ivo Pedruzzi,Sandrine Pilbout,Lucille Pourcel,Monica Pozzato,Manuela Pruess,Catherine Rivoire,Christian J. A. Sigrist,K Sonesson,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Laure Verbregue,Cathy H. Wu,Cecilia N. Arighi,Leslie Arminski,Chuming Chen,Yongxing Chen,John S. Garavelli,Hongzhan Huang,Kati Laiho,Peter B. McGarvey,Darren A. Natale,Karen E. Ross,C. R. Vinayaka,Qinghua Wang,Yuqi Wang,Lai-Su L. Yeh,Jian Zhang,Patrick Ruch,Douglas Teodoro +132 more
TL;DR: The UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal and a credit-based publication submission interface was developed.
Journal ArticleDOI
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Olivier Delattre,Jessica Zucman,Béatrice Plougastel,Chantal Desmaze,Thomas Melot,Martine Peter,Heinrich Kovar,Isabelle Joubert,Pieter J. de Jong,Guy A. Rouleau,Alain Aurias,Gilles Thomas +11 more
TL;DR: Phylogenetically conserved restriction fragments in the vicinity of EWSR1 and EWSR2, the genomic regions where the breakpoints of chromosome 22 and chromosome 11 are, respectively, have allowed identification of transcribed sequences from these regions and has indicated that a hybrid transcript might be generated by the translocation.
Journal ArticleDOI
A census of human RNA-binding proteins.
TL;DR: This work presents a census of 1,542 manually curated RBPs that are analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression, a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.
Journal ArticleDOI
RNA-binding proteins and post-transcriptional gene regulation
TL;DR: The RBPs that interact with pre‐mRNAs and mRNAs are focused on and their roles in the regulation of post‐transcriptional gene expression are discussed.