Journal ArticleDOI
Intestinal helminth infections are associated with increased incidence of plasmodium falciparum malaria in thailand
Mathieu Nacher,Pratap Singhasivanon,Surapon Yimsamran,W. Manibunyong,Nipon Thanyavanich,P. Wuthisen,Sornchai Looareesuwan +6 more
TLDR
It is suggested that a helminth-mediated Th2 shift may have complex consequences on malaria, decreasing antisporozoite immunity, but protecting against severe malaria.Abstract:
In a prospective study of the total population of 5 hamlets on the western border of Thailand, all subjects were screened for helminth infections; during the following year, the incidence of malaria was recorded. Patients were not treated for helminth infections. Among 731 villagers, helminth-infected subjects were more likely to develop falciparum malaria during the following year (adjusted risk ratio 2.24, range 1.4-3.6; P = 0.001). The risk of developing falciparum malaria increased with the number of helminth species (P =0.036). Whereas in other studies helminths were associated with protection from severe complications of malaria, it seemed here that helminth-infected patients were more likely to develop malaria. It is suggested that a helminth-mediated Th2 shift may have complex consequences on malaria, decreasing antisporozoite immunity, but protecting against severe malaria.read more
Citations
More filters
Journal ArticleDOI
Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria
Peter J. Hotez,David H. Molyneux,Alan Fenwick,Eric A. Ottesen,Sonia Ehrlich Sachs,Jeffrey D. Sachs +5 more
TL;DR: It is argued that achieving success in the global fight against HIV/AIDS, tuberculosis, and malaria may well require a concurrent attack on the neglected tropical diseases.
Book ChapterDOI
Global epidemiology, ecology and control of soil-transmitted helminth infections
TL;DR: These are the first estimates at a continental scale to explicitly include the fine spatial distribution of infection prevalence and population, and suggest that continent-wide control of parasites is, from a financial perspective, an attainable goal.
Journal ArticleDOI
Chronic helminth infections induce immunomodulation: Consequences and mechanisms
TL;DR: New insights into these pathways could be useful to antagonize suppression and hence boost vaccine efficacy or to optimize suppression induced by helminth derived molecules and control inflammatory diseases.
Journal ArticleDOI
Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control.
Simon Brooker,Willis Akhwale,Rachel L. Pullan,Benson B. Estambale,Siân E. Clarke,Robert W. Snow,Peter J. Hotez +6 more
TL;DR: Re-analysis of existing data suggests that co-infection with P. falciparum and hookworm has an additive impact on hemoglobin, exacerbating anemia-related malarial disease burden and it is suggested that both school-age children and pregnant women would benefit from an integrated approach to malaria and helminth control.
Book ChapterDOI
Lymphatic Filariasis: Treatment, Control and Elimination
TL;DR: A public health dimension with a focus on affected populations, now supplements the earlier, predominantly patient-oriented clinical approach to LF, and the early uncertainties, then the essential steps leading to this change in outlook are outlined.
References
More filters
Journal ArticleDOI
Common West African HLA antigens are associated with protection from severe malaria
Adrian V. S. Hill,Catherine E. M. Allsopp,Dominic P. Kwiatkowski,Nicholas M. Anstey,Patrick Twumasi,P. Rowe,Stephen Bennett,David Brewster,Andrew J. McMichael,Brian M. Greenwood +9 more
TL;DR: Data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.
Journal ArticleDOI
Severe falciparum malaria.
TL;DR: Children having pulmonary edema, shock and cerebral malaria had high case fatality rate and over all mortality was 9.9%, cerebral malaria being the commonest cause and multi-system involvement was seen in 58.4% cases of death.
Journal ArticleDOI
Vertical transmission of HIV-1 infection
TL;DR: Even if interventions late in pregnancy or around the time of delivery are highly effective in preventing perinatal infection, it is likely that as a public health policy they are of interest only if alternatives to breastfeeding are feasible, affordable, safe and available.
Journal ArticleDOI
The Complexity of Protective Immunity Against Liver-Stage Malaria
TL;DR: Investigation of mechanisms of protective immunity induced by immunization with different vaccine delivery systems in genetically distinct inbred strains, genetically modified mice, and outbred mice establishes that there is a marked diversity of T cell-dependent immune responses that mediate sterile protective immunity against liver-stage malaria.
Journal ArticleDOI
The epidemiology of malaria in a Karen population on the western border of Thailand
Christine Luxemburger,Kyaw L. Thwai,Nicholas J. White,H. K. Webster,Dennis E. Kyle,L. Maelankirri,Tan Chongsuphajaisiddhi,François Nosten +7 more
TL;DR: Findings suggest a higher transmission rate for P. vivax than P. falciparum in a Karen population on the western border of Thailand, although adults still suffered symptomatic malaria due to both species.