Journal ArticleDOI
Investigation of the biological and photophysicochemical properties of new non-peripheral fluorinated phthalocyanines
Çetin Çelik,Nazli Farajzadeh,Mustafa Akin,Göknur Yaşa Atmaca,Özgül Sağlam,Neslihan Saki,Ali Erdoğmuş,Makbule Burkut Koçak +7 more
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In this paper, a series of tetra-substituted phthalocyanines bearing 3,5-bis(trifluoromethyl)phenoxy groups at non-peripheral positions were synthesized.Abstract:
This study presents the synthesis of a series of new tetra-substituted phthalocyanines bearing 3,5-bis(trifluoromethyl)phenoxy groups at non-peripheral positions. The resulting macromolecules were characterized by performing different spectroscopic methods including 1H NMR, UV-Vis, FT-IR, and mass spectroscopy. In this study, the synergistic effect of phthalocyanines used as colorants in ink formulas with other chemicals available was probed for the first time. The synergistic effect of methyl laurate on the biological and antioxidant activities of the compounds (2–5) was investigated. Moreover, the therapeutic properties of the complexes (3, 6, and 7) were investigated using photochemical methods. Upon comparison, complex 7 (ΦΔ = 0.42) was found to be more effective than complex 6 (ΦΔ = 0.40) and complex 3 (ΦΔ = 0.27) in terms of producing singlet oxygen. The results confirmed that the heavy atom effect improves the therapeutic effects.read more
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Photophysicochemical, sonochemical, and biological properties of novel hexadeca-substituted phthalocyanines bearing fluorinated groups.
Nazli Farajzadeh,Çetin Çelik,Göknur Yaşa Atmaca,Sadin Özdemir,Serpil Gonca,Ali Erdoğmuş,Makbule Burkut Koçak +6 more
TL;DR: In this paper, a tetra-substituted phthalonitrile (TSP) was used for photodynamic and sonophotodynamic therapies for the treatment of infectious diseases.
Journal ArticleDOI
Photophysicochemical, sonochemical, and biological properties of novel hexadeca-substituted phthalocyanines bearing fluorinated groups
TL;DR: In this paper , a tetra-substituted phthalonitrile (TSP) was used for photodynamic and sonophotodynamic therapies for the treatment of infectious diseases.
Journal ArticleDOI
Novel symmetrical and unsymmetrical fluorine-containing metallophthalocyanines: synthesis, characterization and investigation of their biological properties.
TL;DR: In this article, a new fluorinated phthalonitrile compound namely 5-bis[4-(trifluoromethoxy)-thiophenyl] phthaloniitrile was synthesized and the results indicated that the highest DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity was determined to be 67.85% for 2 and also 3 showed the highest activity with 31.65% for chelating activity at 200 mg L−1 concentration.
Journal ArticleDOI
Photophysicochemical and Biological Properties of New Phthalocyanines Bearing 4-(trifluoromethoxy)phenoxy and 2-(4-methylthiazol-5-yl)ethoxy Groups on Peripheral Positions.
Nazli Farajzadeh,Sadin Özdemir,Serpil Gonca,Göknur Yaşa Atmaca,Ali Erdoğmuş,Zehra Altuntaş Bayır,Makbule Burkut Koçak +6 more
TL;DR: In this paper, the synergic effect of thiazoles and fluorinated groups on the biological features of phthalocyanines for the first time was evaluated in the hope of discovering efficient pharmaceutical agents.
Journal ArticleDOI
Octa-substituted Zinc(II), Cu(II), and Co(II) phthalocyanines with 1-(4-hydroxyphenyl)propane-1-one: Synthesis, sensitive protonation behaviors, Ag(I) induced H-type aggregation properties, antibacterial–antioxidant activity, and molecular docking studies
Ahmet T. Bilgiçli,Tugberk Kandemir,Burak Tüzün,Rana Arıduru,Armağan Günsel,Çağla Abak,M. Nilüfer Yarasir,Gulnur Arabaci +7 more
References
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Journal ArticleDOI
A survey of Hammett substituent constants and resonance and field parameters
Corwin Hansch,A. Leo,R. W. Taft +2 more
TL;DR: The Hammett equation has been widely used for the study and interpretation of organic reactions and their mechanisms as mentioned in this paper, and it is astonishing that u constants, obtained simply from the ionization of organic acids in solution, can frequently predict successfully equilibrium and rate constants for a variety of families of reactions in solution.
PatentDOI
Fatty acids and derivatives of antimicrobial agents
TL;DR: The structural relationships of 30 straight-chain fatty acids and derivatives and their bactericidal properties were studied and it is indicated that C12 (lauric acid) is the most inhibitory saturated fatty acid against gram-positive organisms.
Journal ArticleDOI
Asymmetric fluorination, trifluoromethylation, and perfluoroalkylation reactions.
Jun-An Ma,Dominique Cahard +1 more